The Procter Gamble Company

Procter & Gamble Pharmaceuticals, Inc.

Norwich Eaton Pharmaceuticals, Inc.

Proctor & Gamble Pharmaceuticals, Inc.

Thomas P Demuth, Jr

Ronald E White

Ronald W White

Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.3, R.sup.4, and R.sup.6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and

Antimicrobial dithiocarbamoyl quinolones

Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.4 and R.sup.6 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and

Antimicrobial lactam-quinolones

A substantially flat collapsed plastic bag with an evacuation form unit insert positioned therein as manufactured to serve as a form about which the filled bag will collapse as it is emptied. The form unit comprises a ring for mounting the unit on the spout of the bag and a multi-channel form extending radially from the ring and hingedly connected thereto. A simple method is provided for manufacturing the bag with the form unit insert.

Antimicrobial carbacephem-quinolones

Compounds of Structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzable esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.

Antimicrobial carbapenem quinolones

The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): ##STR1## wherein (1) R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and

Quinolone 5-(N-heterosubstituted amino) antimicrobials

Compounds of structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzables esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.

Antimicrobial penem-quinolones

Antimicrobial quinolone thiourea compounds of the general formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.3, R.sup.4, and R.sup.6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and

Antimicrobial quinolone thioureas

Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, and R.sup.4 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and

Antimicrobial quinolonyl lactams

Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked, by a non-ester linking moiety, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R.sup.3, R.sup.4, and R.sup.5, together with bonds 'a' and 'b', form any of a variety of lactam-containing moieties similar to those known in the art to have antimicrobial activity;

Antimicrobial quinolonyl lactam esters comprising a lactam-containing moiety linked, by an ester group, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R.sup.3, R.sup.4, and R.sup.5, together with bonds 'a' and 'b', form certain lactam-containing moieties similar to those known in the art to have antimicrobial activity; and

Antimicrobial quinolonyl lactam esters

The present invention provides methods of making compounds of the structure

Process for making antimicrobial quinolonyl lactams

Antimicrobial quinolnyl lactam esters comprising a lactam-containing moiety linked, by an ester group, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R.sup.3, R.sup.4, and R.sup.5, together with bonds 'a' and 'b', form certain lactam-containing moieties similar to those known in the art to have antimicrobial activity; and

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Norwich, NY, United States of America

Thomas P Demuth, Jr