Danmarks Tekniske Universitet

Katholieke Universiteit Leuven

Technical University of Denmark

Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

Myco Teo A/s

Deutsches Krebsforschungszentrum

Thomas Ostenfeld Larsen

Kirk Matthew Schnorr

Lene Lange

Michael Givskov

Thomas Bjarnsholt

Steen Stender

Maria Alhede

Gerit Tolborg

Mhairi Workman

Peter Østrup Jensen

David Tanner

Daniëlle Copmans

Jens Christian Frisvad

Kasper Worm

Annelii Ny

Blanka Leber

Alexander Crawford

Thomas Isbrandt Petersen

Tim Holm Jakobsen

Louise Dahl Hultqvist

Peter De Witte

Alwin Kraemer

Camila Esguerra

Richard Phipps

Sara Kildgaard

Mads Clausen

Niels Høiby

Meenakshi Sundaram Shanmugham

Mads Roennest

Maria Van Gennip

Louise Dahl Christensen

Alwin Krämer

Blanka Rebacz

Mads Hartvig Clausen

Peter ØStrup Jensen

The present invention discloses isoquinolines and 1H-2-Benzopyranes and their use in the treatment and prevention in epilepsy and other seizures. The present invention further discloses methods to screen isoquinoline- and 1H-2-Benzopyran-like molecules as pharmaceutically active compounds.

Treatment for epilepsy

The invention provides a novel class of natural azaphilone pigments, called atrorosins, and methods for their production. The methods for the production of atrorosins include production by fermentation using a fungal species belonging to the genuspreferably the speciesThe use of the novel atrorosins pigments as a colouring agent for food items and/or non-food items, and for cosmetics.

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The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C&#x2550;C&#x2014; bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

Process for the manufacture of ajoene derivatives

The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I). 

Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering

The present invention relates to compounds with structures resembling natural statins isolated fromsp. (Formula I); where Rrepresents OH, CHCOO, RCOO and Rrepresents C&#x2013;Calkyl; Rrepresents H, C&#x2013;Calkyl C&#x2013;Cacyl, Rrepresents H, CH; and X represents a compound of (Formula II) or (Formula III) 

Statin-like compounds

Hand shower and massage brush

Growing community of inventors

Holte, Denmark

Thomas Ostenfeld Larsen