Saltigo Gmbh

Thomas-Norbert Müller

Michael Dockner

What is described is a process for preparing 2-hydroxyacetals of the general formula in which Ris hydrogen, a branched or unbranched C-C-alkyl radical, an electron-deficient, halogen-, NO&#x2014;, CN&#x2014;, CF&#x2014;, acyl group- or branched or unbranched alkyl group-substituted or unsubstituted C-C-aryl or heteroaryl, and Ris a branched or unbranched C-C-alkyl radical, or both Rradicals are bonded directly to one another or to one another via a C-Cunit, by reacting an enol compound of the general formula (II) in which Ris the same and Ris as defined for formula (Ia), with bromine to give the corresponding dibromo adduct and then reacting this dibromo adduct with an alkoxide of the general formula (III) M-O&#x2014;R(III) in which Ris as defined for formula (Ia) and O is oxygen and M is lithium, sodium or potassium. What is likewise described is the preparation of the corresponding 2-hydroxyalkanals from the 2-hydroxyacetals thus obtained by acidic hydrolysis.

Process for preparing 2-hydroxyacetals and the corresponding 2-hydroxyalkanals

The invention relates to a novel process for preparing 2-phenoxyacetals and the corresponding 2-phenoxycarbaldehydes. These compounds are important intermediates for the preparation of active pharmaceutical ingredients.

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Monheim, Germany

Thomas-Norbert Müller