Louisiana State University and Agricultural & Mechanical College

Thomas N Tully, Jr

Konstantin G Kousoulas

Vladimir N Chouljenko

Abolgasem Baghian

Vaccine compositions protective againstinfections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of amajor outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding amajor outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or 'naked nucleic acid' vaccination are disclosed. Methods for preventing ainfection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.

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Vaccine compositions protective against infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding a major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or &ldquo;naked nucleic acid&rdquo; vaccination are disclosed. Methods for preventing a infection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.

Growing community of inventors

St. Francisville, LA, United States of America

Thomas N Tully, Jr