Ibis Biosciences, Inc.

Thomas N Chiesl

Steven Gerald Haupt

Michelle Toro

Mark W Eshoo

Jared James Drader

John Picuri

Jose R Gutierrez

Stanley T Motley

Karl M Cabrera

The present disclosure relates to systems and methods for nucleic acid isolation from cellular samples. In particular, the present disclosure provides systems and methods for lysing cells and recovering nucleic acids.

Systems and methods for isolating nucleic acids from cellular samples

The invention relates generally to compositions and methods for disrupting cells (e.g., disrupting cellular and nuclear membranes). In particular, the invention provides modified solid surfaces (e.g., bead surfaces) and their use in disruption of cellular membranes (e.g., during cellular lysis procedures (e.g., for recovery of nucleic acid (e.g., DNA or RNA) from mechanical cell lysis)). Compositions and methods of the invention find use in a wide range of applications including molecular biology and medical science.

Compositions and methods for sample preparation

Provided herein are apparatuses and methods for fragmenting nucleic acids or disrupting cells. For example, some embodiments provide a disposable microfluidic device designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells.

Microfluidic transducer

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Hurcules, CA, United States of America

Thomas N Chiesl