Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Thomas Muller

Johannes M Weisenberger

Wolfgang Eisert

Volkhard Austel

Helmut Pieper

Gunter Linz

Armin Heckel

Brian Guth

Frank Himmelsbach

Berthold Narr

Josef Nickl

Erich Muller

Rainer Soyka

Gojko Muacevic

Josef Nickl, Deceased

F Himmelsbach

Christopher Meade

Helmut Franz

Wolfgang Fisert

The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.

Biphenyl derivatives, pharmaceutical compositions containing these

The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.

Cyclic urea derivatives, pharmaceutical compositions containing these

The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.

Cyclic dericatives, pharmaceutical compositions containing these

The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 production.

Arylsulphonamides, pharmaceutical compositions containing these

Cyclic compounds and pharmaceutical compositions containing them

Pharmaceutical composition for prevention of adhesions to body organs or parts of body organs within a body cavity at a site of inflammation is disclosed. The pharmaceutical composition contains t-PA and an aqueous hydroxyethylcellulose hydrogel. The method involves applying the aforementioned pharmaceutical composition to a site of inflammation in a body cavity.

Methods and preparations for preventing adhesions to organs and parts of

Cyclic derivatives pharmaceutical compositions containing these

This invention relates to pyridyl derivatives of the formula ##STR1## wherein X, Y, A, n and R.sub.3 to R.sub.8 are defined hereinbelow, the enantiomers thereof, the cis- and trans-isomers thereof, which have antithrombotic pharmaceutical activity.

Pyridyl derivatives and pharmaceutical compositions comprising these

The invention relates to carboxylic acid derivatives of general formula

Carboxylic acid derivatives, pharmaceutical compositions containing

Arylsulphonamides, pharmaceutical compositions containing these compounds

A method for the prevention of adhesions to body organs and parts of organs caused by therapeutic intervention by applying a pharmaceutical composition of tissue plasminogen activator and an aqueous hydroxyethylcellulose hydrogel.

Methods for preventing adhesions to organs and parts of organs by

The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH) They also have an effect on PGE.sub.2 production.

Arylsulphonamides pharmaceutical compositions containing these compounds

The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.

Growing community of inventors

Biberach, Germany

Thomas Muller