The Hong Kong University of Science and Technology

The Hong Kong Polytechnic University

Thomas Ming Hung Lee

I Ming Hsing

Kwun Fung Wong

Shea Ping Yip

Stephen Siu Wai Yeung

A method for stabilizing conjugates between macromolecule and nanoparticle by forming a thin reinforcement layer over the surface of a nanoparticle after macromolecule chains have attached to the surface of the nanoparticle. The stabilized conjugates can be used in a wide range of applications such as in vitro diagnostics, in vivo imaging and therapeutics, which need to be conducted under various severe or harsh conditions.

Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation

A method and device for real time electrochemically or electrically monitoring and detecting nucleic acid amplification products, i.e. after each polymerase chain reaction cycle, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric signals are measured during a PCR amplification process to the electrodes that is suitable for quantifying the amplified products of a sample's nucleic acid(s) produced. This technique is suitable for point-of-use applications, e.g. detecting bioanalytes in remote locations.

Growing community of inventors

Hong Kong, China

Thomas Ming Hung Lee