University of California

Pfizer Corporation

Thomas Mikita

Shaun R Coughlin

Isaac J Rondon

Yun Cheol Kim

Lauren K Ely

Tovo David

Huilan Gao

In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.

Antibodies to coagulation factor XIa and uses thereof

Growing community of inventors

Sausalito, CA, United States of America

Thomas Mikita