Cedars-sinai Medical Center

Thomas Michael Kremen

Dan Gazit

Gadi Pelled

Tendon and ligament injuries are common in orthopaedic clinical practice and cause substantial morbidity in sports and in routine daily activities. While surgical reconstruction is effective, the majority of patients suffer from a prolonged period of recovery because of limited regeneration capacity of the tendon-bone interface. Here, the Inventors have established an approach for promoting tendon/ligament integration. By first recruiting endogenous stem cells to the site of injury, bone morphogenic proteins (BMPs), are then delivered in vivo to promote repair. Significant acceleration of healing via the above methods and compositions leads to fast recovery and return to normal activities, thereby providing new therapeutic avenues for treatment of injuries involving the tendon-bone interface.

Method of endogenous stem cell activation for tendon/ligament osseointegration

This disclosure describes providing message encryption through identification of sequential prime numbers. Encryption keys are generated, where a public encryption key is generated based on determining a lowest addend value to add to a starting value to produce a next sequential prime number with respect to the starting value. The public encryption key is provided to a computing device, and the computing device can use the public encryption key to encrypt a message. The encrypted message is received from the computing device and decrypted using a private key of the encryption keys that are generated.

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Dublin, CA, United States of America

Thomas Michael Kremen