Dr. Karl Thomae Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Oncotest Gmbh

Thomas Metz

Frank Himmelsbach

Birgit Jung

Elke Langkopf

Georg Dahmann

Flavio Solca

Thomas Von Ruden

Anke Baum

Stefan Matthias Blech

Heinz-Herbert Fiebig

Niko Bausch

André Korrat

Martina Maurer

Julia Schüler

The present invention relates to bicyclic heterocycles of general formula wherein

Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them

The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.

Gene expression profiles being predictive for the response of tumors to pharmaceutically effective compounds

The present invention relates to bicyclic heterocycles of general formula wherein Rto R, A to E and X are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.

The present invention relates to bicyclic heterocycles of general formulawherein

4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases

Pyrimido[5,4-d]pyrimidines of the general formula ##STR1## which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of oncoses, and their preparation. Exemplary compounds are:

Pyrimido [5, 4-d] pyrimidines, pharmaceuticals containing these

Pyrimido�5,4-d!pyrimidines of the general formula ##STR1## which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of disorders, in particular of oncoses, and their preparation. Exemplary compounds are:

Pyrimido�5,4!-dipyrimidines, pharmaceuticals containing them, their use

The present invention relates to pyrimido�5,4-d!pyrimidines of the general formula ##STR1## in which R.sub.a to R.sub.c are as defined herein, their tautomers, their stereoisomers and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibiting action on signal transduction mediated by tyrosine kinases, their use for the treatment of diseases, in particular tumor diseases.

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Glottertal, Germany

Thomas Metz