Bausch-lomb Incorporated

Thomas Menzel

David J Heiler

Susan E Burke

X Michael Liu

Abbie Brongo

Karl Cummins

Zhenze Hu

Howard C Epstein

David Joseph Heiler

Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 &#x3bc;m or less to provide a sterilized high salt, hyaluronic acid solution.

Sterile hyaluronic acid solutions

A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40&#xb0; C. to 80&#xb0; C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.

The present invention is a skin care composition which provides a high degree of moisturization without leaving a 'tacky' residue on treated skin. The subject composition comprises; (a) from about 2 to about 10 weight percent of a quaternary ammonium compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each alkyl groups having from about 16 to about 22 carbon atoms, R.sub.3 and R.sub.4 are each lower alkyl groups having from about 1 to about 3 carbon atoms, and X is a salt-forming anion, (b) from about 1 to about 40 weight percent of a humectant, and (c) from about 0.01 to about 5 weight percent of non-irritating hydrophobic polymeric microspheres having an average particle size of less than about 50 microns.

Skin care compositions

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Rochester, NY, United States of America

Thomas Menzel