Astrazeneca Ab

Dainippon Sumitomo Pharma Co., Ltd.

Astra Zeneca U.k. Limited

Sumitomo Dainippon Pharma Co., Ltd.

Astra Pharmaceuticals Limited

Fisons Ltd.

Astrazeneca Aktiebolag

Thomas McInally

Stephen Thom

Andrew Baxter

Stephen Brough

Roger Victor Bonnert

Michael P Mortimore

Alan C Tinker

Nicholas David Kindon

David Cladingboel

Bryan Glyn Roberts

Nicholas James Bennett

Brian Springthorpe

Matthew Wd Perry

Peter Richard Hamley

Hiroki Wada

Tobias Mochel

Stephen J Brough

Andrew J G Baxter

Alan Wellington Faull

Yoshiaki Isobe

Craig Johnstone

Kazuki Hashimoto

Austen Pimm

Timothy Jon Luker

John Dixon

John Graham Cumming

Garry Pairaudeau

Jeremy Nicholas Burrows

Ayumu Kurimoto

Anil Patel

Anna-Karin Tidén

Richard Evans

Rukhsana Tasneem Mohammed

Rukhsana Rasul

Ian Millichip

Andrew J Baxter

Satoshi Onuma

David Marriott

Andrew Davies

Haydn Beaton

Phillip Abbott

Nicholas Kindor

David Harden

Andrew Davis

The invention concerns compounds of Formula (I): wherein L, R, R, R, Rand X are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer. 

Pyrimidine derivatives and their use in the treatment of cancer and further diseases

Disclosed herein are a compound of formula (I) and pharmaceutically acceptable salts thereof, processes for preparing the same, pharmaceutical compositions containing the same, and methods of using the same. 

Imidazoquinoline compounds

The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy. 

Purine derivatives

The present invention provides compounds of formula (I) wherein R, R, Rand Rare as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Pyrimidline derivatives having immune modulating properties that act via TLR7 for the treatment of viral or allergic diseases and cancers

Compounds

The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. 

The present invention provides compounds of formula (I) wherein R, Y, X, L and Rare as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators

The present invention provides compounds of formula wherein R, Y, X, Z, X, Y, A, n and Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

The present invention provides compounds of formula where n, R, R, A, X, Y, Z, Xand Yare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators

The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Zrepresents alkylene, Xrepresents oxygen atom, sulfur atom, SO, NR, CO, CONR, NRCO and the like, Y, Yand Yrepresent independently a single bond or an alkylene group, Xrepresents oxygen atom, sulfur atom, NR(Ris hydrogen atom or an alkyl group) or a single bond, Rrepresents a substituted or unsubstituted alkyl group, Rrepresents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

9-substituted 8-oxoadenine compound

The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R, Rand X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Substituted Thiophene compounds

The invention concerns compounds of formula (I), wherein the variables are defined herein; processes for preparing them, compositions comprising them and their use in modulating CCR5 receptor activity.

Ccr5 modulators benzimidazoles or benzotriazoles

The invention provides a compound of formula (I): wherein R, R, R, R, R, N, X and Y are as defined in the specification, processes, for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions.

Chemical compounds

The invention provides compounds of general formulawherein R, m, Q, T, n, R, R, V, W, X and Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

The invention provides compounds of formula (I) wherein R, R, R, R, Z, Q, m, n, X, X, X, Xand T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions

Substituted piperidine compounds useful as modulators of chemokine receptor activity

Growing community of inventors

Loughborough, United Kingdom

Thomas McInally