Bristol-myers Company

Bristol-myers Squibb Compnay

Thomas M Tencza

Mahesh K Patell

F Henry Merkle

Howard Jones

Alison B Lukacsko

Mahesh K Patel

Beth A Sarsfield

Gerard Frunzi

Chung-Bin Kim

Eugene G Press

A tamper-resistant dosage form capsule for the oral administration of therapeutic agents comprises a two-part capsule which is shrunk around a caplet so that the outer wall of the caplet is bound to the inner walls of both parts of the capsule. The caplet is placed into the capsule, and the dosage form is then subjected to relatively high humidity and temperature conditions, followed by drying the dosage form in a lower humidity environment, so that the capsule is shrunk to conform to the contours of the caplet and both parts of the capsule are bonded to the caplet.

Capsule and caplet combination

An analogesic tablet containing aspirin, acetaminophen and caffeine of improved dissolution rate containing low-substituted hydroxypropylcellulose.

Analgesic tablet of aspirin and caffeine containing low-substituted

A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of aspirin or ibuprofen and a diuretic from the group pamabrom and hydrochlorothiazide; optionally it may also contain an antihistamine.

Pharmaceutical compositions for relief of dysmenorrhea and/or

A capsule shaped tablet containing a pharmaceutically active ingredient in which the tablet has a cap portion and a body portion physically bound to each other; the cap portion having a larger outside diameter than the body; the tablet may be provided with a coating of a film forming polymer to simulate a hard gelatin capsule dosage form.

Capsule shaped tablets

The invention relates to an oral pharmaceutical composition containing benzonatate. More particularly it concerns a composition of this character having improved taste and demulcency characteristics as well as one which minimizes the local anaesthesia to the oral muscosa brought about by the benzonatate.

Antitussive composition

An analgesic capsule containing asprin and APAP. The aspirin is in the form of an enteric coated granule, and the APAP is present in powder form.

Analgesic capsule

A capsule product preferably containing a high dosage of aspirin in powder or granulated form and at least one akaline tablet or pellet; the improvement in which said alkaline tablet or pellet comprises magnesium carbonate, calcium carbonate and a magnesium oxy component such as magnesium oxide, magnesium hydroxide or the combination of magnesium oxide and magnesium hydroxide. The alkaline tablet is preferably dimensioned so that it will contain a maximum amount of material in a minimum volume e.g. a spheroid so that it can be readily dropped into a gelatin capsule e.g. #0 gelatin capsule.

Capsule product containing high dosage of aspirin in powder or

There is disclosed a capsule containing aspirin and alternatively other active analgesic materials in combination with an alkaline material. The composition is made stable by providing the alkaline material in a tablet form.

Growing community of inventors

Wallington, NJ, United States of America

Thomas M Tencza