Leland Stanford Junior University

Harvard College

Thomas M Snyder

Stephen R Quake

Hannah Valantine

David R Liu

Matthew William Kanan

Daniel M Rosenbaum

Zev J Gartner

Christopher T Calderone

Xiaoyu Li

Jeffrey B Doyon

Matthew W Kanan

The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.

Non-invasive diagnosis of graft rejection in organ transplant patients

Nucleic acid sequencing apparatus for monitoring status of a transplant recipient

The disclosure provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. The methods comprise determining the presence or absence of one or more nucleic acids from a donor transplant, wherein said one or more nucleic acids from said donor are identified based on a predetermined marker profile, and diagnosing or predicting transplant status or outcome based on the presence or absence of said one or more nucleic acids.

Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

Evolving new molecular function

Growing community of inventors

Palo Alto, CA, United States of America

Thomas M Snyder