Adaptive Biotechnologies Corporation

Other

Thomas M Snyder

Harlan Saul Robins

Mark Klinger

Jonathan M Carlson

Julia Greissl

Provided are methods for assessing T cell receptor β chain complementary determining region 3 (TCRβ CDR3) sequences. In certain embodiments, the methods comprise assessing TCRβ CDR3 sequences determined from a sample obtained from a subject having or suspected of having a tick bite for the presence or absence of one or more TCRβ CDR3 sequences set forth in the present disclosure. According to some embodiments, at the time of the assessing, the subject is seronegative for Lyme disease and/or has one or more non-specific symptoms consistent with Lyme disease. Also provided are methods comprising administering a Lyme disease therapy to a subject identified as comprising T cells that express a T cell receptor β chain (TCRβ) comprising a TCRβ CDR3 sequence set forth in the present disclosure.

Lyme disease-associated T cell receptor-related methods

Provided are methods of assessing a biological sample obtained from an individual for the presence of a T cell that expresses a T cell receptor (TCR) comprising a TCRβ CDR3 sequence set forth in Table 1. Such methods further comprise identifying the individual as having COVID-19 when the presence of the TCR is detected. The presence of one or more of these TCRs may be of use in prognosticating severity of COVID-19 in the individual and the individual may be treated based on the expected severity of COVID-19. Treatment methods may include administering to the individual a T cell engineered to express the TCR. Such engineered T cells are also disclosed. Also provided are compositions and multimers that find use, e.g., in practicing the methods of the present disclosure.

T cell receptor sequences diagnostic for COVID-19 and related compositions

Flexible brackets or &ldquo;wings&rdquo; molded from marine grade, UV resistant PVC allow attachment of inflatable boat fenders to any piling or dock structure regardless of shape or size. Adjustable straps are used to encompass the fender and fasten it to the &ldquo;wings&rdquo; allowing use of any size fender from six to twelve inches in diameter. A short section of line is used to secure the fenders, when used vertically, to an eye screw fastened to the piling or structure in a location above the fenders where the line can pass through the central opening in the fenders and tie in a large knot at the bottom of the fenders.

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San Bruno, CA, United States of America

Thomas M Snyder