Schering Corporation

Synaptic Pharmaceutical Corporation

H. Lundbeck A/s

Thomas M Laz

Suke Wang

John A Salon

Raisa Nagorny

Joseph A Hedrick

Shelby P Umland

Jiang X Behan

Kelley L Morse

Amy E Wilson

Frederick J Monsma

Ling Pang

Frederick James Monsma, Jr

Amy F Wilson

The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

Histamine receptor

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

Methods of identifying melanin concentrating hormone receptor antagonists

Histamine receptor antibody

The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.

Leukotriene receptor

DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof

Polynucleotide encoding a histamine receptor

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Parlin, NJ, United States of America

Thomas M Laz