Unigen Pharmaceuticals, Inc.

Unigen Corporation

Univera Pharmaceuticals, Inc.

Thomas M Farrow

Qi Jia

Belaid Mahiou

Zhihua Qiu

Ajith Nissanka

The present disclosure describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. The present disclosure also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. Included in this disclosure is an improved method to isolate and purify 7-hydroxychromones from plant sources.

7-hydroxy chromones as potent antioxidants

The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administering an effective amount of a 7-hydroxychrome or a mixture of 7-hydroxychromones. The present invention includes methods that are effective in inhibiting free radical and oxidation caused damage through the simultaneous suppression of free radical generation and the suppression of the production of reactive oxygen species (ROS). The present invention also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. The method for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes is comprised of administering to a host in need thereof an effective amount of a composition comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones and a pharmaceutically acceptable carrier. Included in this invention is an improved method to isolate and purify 7-hydroxychromones from plant sources.

7-Hydroxy chromones as potent antioxidants

The present invention relates generally to a method for the purification of aloesin, a C-glucosylated 5-methylchromone, tyrosinase inhibitor isolated from Aloe. Specifically, the present invention relates to a method for the crystallization of aloesin, that produces highly pure, relatively colorless aloesin

Method for purification of aloesin

The present invention provides a method for the prevention and treatment of chronic venous insufficiency. Specifically, the present invention provides a method for the prevention and treatment of varicose veins, particularly hemorrhoids by application of an effective amount of an isoquinoline alkaloid. Included in this invention is an improved method for isolating and purifying alkaloids, particularly isoquinoline alkaloids from plants.

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Denver, CO, United States of America

Thomas M Farrow