Depuy Synthes Products, Inc.

Depuy Spine, Inc.

Codman & Shurtleff, Inc.

Janssen Pharmaceutica Nv

Medos International Sarl

Thomas M DiMauro

Mohamed Attawia

Hassan A Serhan

Michael Andrew Slivka

Jeffrey Karl Sutton

Sean Lilienfeld

John Daniel Malone

Sudhakar Kadiyala

David J Urbahns

Chantal Holy

Scott Bruder

William C Horton

Melissa Grace

Richard C Pellegrino

John S Crombie

Martin A Reynolds

Laura Brown

Michael Ward

Jeffrey C Geesin

Lauren Aquino Shluzas

Michael J O'Neil

Terri Kapur

Vivek N Shenoy

Thomas G Ferro

Alonzo D Cook

Gregory Collins

Kevin Wildenhaus

James Edward Kelly

Joern Richter

Michael Alan Fisher

Kevin L Cooper

Daniel Thommen

Michael D Sorrenti

Alexandru Paunescu

Timothy Beardsley

Edward B Zalenski

Charles M Bartish

Pamela Lynn Plouhar

Hugo A Pedrozo

Christopher Rogers

Patrick Fatyol

John J Siekierka

Bradley Thomas Moore

Hal Brent Woodrow

Richard Toselli

Tim Beardsley

John Pracyk

Michael Luedtke

Alexander Samaha

Griffin Cummings

Jeff Geesin

Catherine Smith

Kathryn Anne Rohr

Laura J Brown

David Urbahns

The use of red or near infrared light upon neurons of the lumbar plexus that are in distress due to retraction-induced ischemia. The surgeon may protect nerves made ischemic in the surgery by:

NIR/red light for lateral neuroprotection

This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.

Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor

An orthopedic device for implanting between adjacent vertebrae comprising: In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

In-situ intervertebral fusion device and method

Disclosed herein are hydroxyethylquercetin glycosides, including compounds of Structural Formulas I, II, III and IV. The compounds disclosed are useful for inhibiting norepinephrine metabolism and treating antenatal and postnatal depression in subjects in need thereof.

Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide

NIR/RED light for lateral neuroprotection

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

In-situ formed intervertebral fusion device and method

A device adapted to deliver red/NIR light through an eyelid of a patient, the device comprising:

Trans-orbital infrared light therapy

An expandable intervertebral fusion cage is independently expandable vertically and laterally. The fusion cage includes a cage body that can receive an expansion member that causes the fusion cage to expand vertically. The cage body is responsive to a compressive force to move to an expanded lateral position, whereby the fusion cage defines a substantially circular annular profile.

Expandable intervertebral fusion cage

An NIR light emitting device has a flat NIR light emitter attached to a distal end of a heat pipe on its lower side and an optically-transparent, thermal insulator on its upper side. The proximal end of the heat pipe is thermally connected to a cooling element. The light emitter is connected to a power source to irradiate NIR light.

Transorbital NIR LIGHT THERAPY DEVICES

A device for treating the brain includes a light source configured to emit near infrared light. The device also includes a collimator configured to receive the near infrared light emitted by the light emitter. The collimator is further configured to collimate the near infrared light. The device also includes an optic configured to focus collimated light. A reflector of the device is configured to change a direction of the collimated light. The reflector is at a distal end of the device, and the distal end is configured to fit between an upper portion of an eyelid of a patient and an orbital socket of the patient.

Transorbital NIR light therapy device

Disclosed herein are metabolites of hydroxyethylrutoside (hydroxyethylquercetin-7-O-glucuronide), including compounds of Structural Formulas I, II, III and IV. The compounds disclosed are useful for inhibiting norepinephrine metabolism and in treating antenatal and postnatal depression in subjects in need thereof.

Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide metabolite

Growing community of inventors

Southboro, MA, United States of America

Thomas M DiMauro