The Upjohn Co.

Thomas M Castle

Lester A Dolak

Alice L Laborde

Fritz Reusser

Betty R Hannon

Charles K Marschke

Oldrich K Sebek

Thomas F Brodasky

Alexander D Argoudelis

Novel antibiotic U-68,204 is produced in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces thiolactonus, NRRL 15439. This antibiotic is active against various Gram-positive bacteria. Thus, antibiotic U-68,204 can be used in various environments to eradicate or control such bacteria.

Antibiotic producing Streptomyces thiolactonus

Composition of matter and process

Antibiotic U-66,026 is produced in a fermentation under controlled conditions using the microorganism Alcaligenes sp., NRRL B-15269. Enhanced fermentation of titers U-66,026 are obtained when Alcaligenes sp., NRRL B-15269, is cultivated in mixture with Streptomyces plicatus strain 395, NRRL 15273. Antibiotic U-66,026 is a useful antibiotic which has antifungal activity.

Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.

Antibiotic producing streptomyces

Novel antibiotic U-64,767 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces macronensis Dietz sp.n., NRRL 12566. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus pyogenes. It is also active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-64,767 can be used in various environments to eradicate or control such bacteria.

Process for production of antibiotic U-64,767 using Streptomyces

Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria. Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##

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Cooper Township, Kalamazoo County, MI, United States of America

Thomas M Castle