Bayer Aktiengesellschaft

Bayer Corporation

Thomas M Aune

Eckhard Schwenner

Gaetan Ladouceur

Hans-Joachim Kabbe

The present invention comprises new methods for treating rheumatoid arthritis. It has been found that the L-type calcium channel antagonists are effective in treating arthritis. Nimodipine, nisoldipine, and nifedipine, are examples of specific compounds useful in the present invention.

Inhibition of arthritis by L-type calcium channel antagonists

The anthracene-spiro-pyrrolidines according to the invention are prepared by reacting either anthracene-spiro-furans or unsubstituted anthracene-spiropyrrolidines with appropriately substituted amines or by reacting unsubstituted anthracene derivatives with appropriately substituted methylenepyrrolidines. The substances can be used as active agents in medicaments, in particular for the production of immunomodulating medicaments.

Anthracene-spiro-pyrrolindines

N,N-Disubstitued piperazines are prepared by reacting either the appropriately substituted furans or the N-unsubstituted pyrrolidines with aminoalkylpiperazines. The substances according to the invention can be employed as active agents in medicaments, in particular for the production of immunomodulators.

N,N-disubstituted piperazines

Substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes or N-unsubstituted pyrroloanthracenes with appropriately substituted alkylamines. The compounds can be employed as active ingredients in medicaments, in particular as immunomodulators.

Substituted pyrroloanthracenes and -diones

The piperazine-substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes with piperazinalkylamines or reacting unsubstituted pyrroloanthracenes first with dihalogenoalkyl compounds and then with appropriately substituted piperazines or by reacting furan derivatives first with piperazinalkylamines and then condensing with anthracenes. The new compounds can be employed as active ingredients in medicaments, in particular in immunomodulators.

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Hamden, CT, United States of America

Thomas M Aune