Hoffmann-la Roche Inc.

Genentech, Inc.

F. Hoffmann-la Roche Ag

Thomas Luebbers

Jens-Uwe Peters

Patrizio Mattei

Luca Claudio Gobbi

Wolfgang Haap

Holger Kuehne

Bernd Kuhn

Alexander Alanine

Lucinda Steward

Synese Jolidon

Philippe Pflieger

Karlheinz Baumann

Cyrille Maugeais

Sabine Kolczewski

David Banner

Erwin Goetschi

Olivier Roche

Alexander Flohr

Werner Mueller

Daniel Hunziker

Robert Narquizian

Anja Limberg

Aurelia Conte

Lilli Anselm

Helmut Jacobsen

Beat Spinnler

Emmanuel Pinard

Mark Rogers-Evans

Georg Jaeschke

Werner Neidhart

Andrew William Thomas

Hans G Richter

Rainer Eugen Martin

Jean-Marc Plancher

Wolfgang Guba

Konrad H Bleicher

Luke Green

Markus Rudolph

Markus Boehringer

Jerome Hert

Pierre Charles Wyss

Dagmar Kube

Gisbert Schneider

Jochen Zuegge

Henner Knust

Michelangelo Scalone

Tanja Schulz-Gasch

Hans Peter Wessel

Rosa Maria Rodriguez Sarmiento

Fabienne Ricklin

Rosa Maria Rodriguez-Sarmiento

Guido Hartmann

Bernd Michael Loeffler

Delphine Gaufreteau

Jean-Baptiste Blanc

Christoph Faeh

Aurelia Conte-Mayweg

The invention provides novel compounds having the general formula (I) wherein R, R, R, Rand W are as defined herein, compositions including the compounds and methods of using the compounds.

Phenoxymethyl derivatives

The invention relates to a compound of formula (I) wherein Rand Rare defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Pyrrolidine derivatives

The invention relates to a compound of formula (I) wherein A, Aand Rto Rare defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Pyridine derivatives

The invention relates to a compound of formula (I) wherein A, B, D and Rto Rare defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Cyclic amides

The invention relates to compounds of formula wherein the substituents are as described in claim. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &#x3b2;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

Modulators of amyloid beta

The invention relates to a compound of formula (I) 

Azetidine derivatives

The invention relates to a compound of formula (I) wherein Ato Aand Rto Rare defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

The invention relates to a compound of formula (I) wherein A and Rto Rare defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

The present invention relates to compounds of formula I hetaryl I, hetaryl II, R, R, R, Y,m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &#x3b2;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

Bridged piperidine derivatives

The invention relates to compounds of formula where hetaryl I, hetaryl II,

Heteroaryl substituted piperidines

The present invention relates to compounds of the general formula as dual modulators of the 5-HTand Dreceptors useful against CNS disorders, wherein A, R, R, n, p, q and r are as defined in the specification.

[object Object]

The invention relates to compounds of formula wherein R, R, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compounds of formula I are modulators for amyloid beta and may be useful for the treatment or prevention of a disease associated with the deposition of &#x3b2;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

Modulators for amyloid beta

The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise administering a therapeutically effective amount of a compound of formula I whereinR, R, R, V, W, Y, and Z are as defined herein or a pharmaceutically active acid addition salt of such compounds. The invention also relates to a subgenus of such compounds and pharmaceutical compositions containing them, as well as methods for their manufacture.

Heterocyclic gamma secretase modulators

Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors

Growing community of inventors

Loerrach, Germany

Thomas Luebbers