Sartorius Stedim Biotech Gmbh

Thomas Loewe

Sebastian Handt

Thomas Friese

Paschalis Nikoloudis

Ralf Lausch

Maik Sommer

Andre Dell

Volkmar Thom

Bernhard Diel

Shahmir Fatherazi

Johannes Wortmeyer

Holger Linne

Wilhelm Requate

Ashok Mundrigi

Ramesh Mundlamuri

Jahnavi Gowda

Ellen Schuessler

Oscar-Werner Reif

Gerhard Greller

Ute Husemann

Gerid Hellwig

Bjoern Hansmann

Thomas Dreher

Katrin Müller

Björn Hansmann

Mario Strauss

Mandar Dixit

Florian Mieth

André Dell

Ellen SCHÜSSLER

A method for providing an integrity test of a double filter capsule can include providing the double filter capsule in such a way that in a filtration process the medium to be filtered flows in its flow direction from an upstream chamber in the housing through a first filter into an intermediate chamber between the first filter and a second filter and then through the second filter to an outlet. The housing can have an upstream-chamber access point for feeding a test fluid into the upstream chamber and an intermediate-chamber access point for feeding the test fluid into the intermediate chamber. Additional steps can include providing a connecting line between the upstream-chamber access point and the intermediate-chamber access point and determining the state of integrity of the double filter capsule on the basis of at least two test phases.

Integrity test for a double filter capsule

A disposable filter capsule for a filtration device comprises only one housing, which has an inflow connection for a fluid to be filtered and an outflow connection for filtrate. The disposable filter capsule also comprises at least two separate filter means, which are fixed in the housing and together with the housing form an inseparable structural unit. All the components of the disposable filter capsule consist of sterilizable, in particular gamma-sterilizable, materials.

Disposable filter capsule for a filtration device

A single-use filtration device including a plurality of single-use filter capsules connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder. The filter capsules, in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules, are preconfigured for a desired filtration process.

Preconfigured single-use filtration device

A filtration device, in particular a disposable filtration device, has a flow path in which a filter element and an integrated flow reducer are arranged one behind the other. The flow reducer is adapted to be brought to a first operating position, which permits a defined first volume flow rate, and at least to a second operating position, which permits a defined second volume flow rate which is smaller than the first volume flow rate.

Filtering apparatus comprising an integrated flow reducer, and method for completely imbibing a filter membrane

A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f) re-rinsing with high flow; and g) closing the main line; wherein the process steps f) and g) are optional.

Method for filtering a large volume of a medium with a pre-sterilisable, at least semi-automated one-way filtration device

A single-use device for filtration of a large volume of medium including a plurality of single-use filter units, at least some of which, preferably all of which, are connected to each other by rigid pipes. The filter units include at least one prefilter and at least one main filter for virus filtration which is configured as a hollow fiber capsule.

Disposable device for filtering a large medium volume

A filter module for sterile filtration and virus filtration of fluid media. The filter module includes a filter membrane with a porous edge structure arranged thereon and at least one anchoring element. The filter membrane with the porous edge structure is embedded in the anchoring element and serves as edge reinforcement to improve the connection of the filter membrane to the anchoring element. The texturing or surface roughness of the edge reinforcement provides an interlocking effect between the filter membrane and the anchoring element. The embedding of the filter membrane in the anchoring element provides a fluid-tight connection of the membrane to the anchoring element which prevents the occurrence of leaks in the end region of the filter module. A method for producing the filter module is also described.

Filter module having an edge-reinforced membrane, method for producing the filter module and use thereof

A protective device () is provided for a hose clip () that connects a hose end () to a hose connection (). The protective device includes a protective body () made of a plastic. In the assembled state, the protective body () surrounds the circumference of the hose clip () and accommodates the hose clip () at least in its clamping region via a radially oriented molding (), and covers the hose clip () over the width thereof extending in the longitudinal direction of the hose connection (). The protective body () has ring segments () that can be connected to one another at their free ends (), and the segments are connected moveably to one another at their ends () facing away from the free ends ().

Protective device for a hose clip

A valve includes a longitudinally movable valve body that is arranged in the valve, wherein the valve housing has at least two guide grooves, with which auxiliary guide elements, arranged on the valve body, engage an exterior surface of the valve housing. The guide grooves of the valve housing are shaped such that they define a combined translatory and rotary movement path of the valve body with the aid of the auxiliary guide elements in order to open or close the valve.

Stabilized valve with guide

The present invention relates to a porous sheet product, to a filter element comprising the porous sheet product, to a method for producing the porous sheet product, to a method for producing the filter element, and to the use of the sheet product and of the filter element.

Porous textile fabric, filter element, method for the production thereof and use thereof

A disposable filtration device includes a plurality of disposable filter capsules connected with each other by lines, which are carried by a rigid holder. At least the holder and the lines between the filter capsules preferably are formed of a sterilizable material, so that the filtration device can be sterilized in the pre-mounted, i.e. ready-to-connect condition, and can be packed and transported without a risk of damage.

Disposable filtration device

The present invention relates to a melt-joined filter element with improved testability after dry steaming or alternatively after sterilization by irradiation, to a method for producing the filter element according to the invention, and to the use of the filter element for filtering solutions.

Filter element with improved testability after dry steaming

A filter module with a perforated inner tube () and a concentric, perforated outer tube (), forming an interposed annular gap for a filter membrane () pleated into folds. The membrane folds (, . . . ) are of different fold types with differing fold heights, extend from a respective fold edge (, . . . ) resting against the outer tube towards the inner tube to the respective fold tip (, . . . ) and are arranged along the circumference of the annular gap as groups of folds (, . . . ) of different types. Each group has a mating fold () which extends from a mating fold edge () resting against the inner tube towards the outer tube to the mating fold tip (). The height of the mating fold is no more than the difference between the width of the annular gap and the height of the fold type with the shortest height of the same group.

Filter module

The present invention relates to a micro-porous filtration membrane with performance enhancing projections as well as a method for producing the same.

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Goettingen, Germany

Thomas Loewe