Acucela Inc.

Omeros Corporation

Ceptyr, Inc.

Myriad Genetics, Inc.

Thomas Little

Feng Hong

Mark W Orme

Ian L Scott

Vladimir Aleksandrovich Kuksa

Anna S Gall

Jennifer Lynn Gage

Ryo Kubota

Thomas N Wheeler

Neil S Cutshall

Maher Qabar

William C Patt

Mark Arnold Thomas Blaskovich

Gangadhar Nagula

Ted Baughman

James Jeffry Howbert

Danwen Huang

Marcin Stasiak

Jessymol Mathew

Lauri Marie Schultz

Lauri Mario Schultz

Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

PDE10 inhibitors and related compositions and methods

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Alkoxy compounds for disease treatment

Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Amine derivative compounds for treating ophthalmic diseases and disorders

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Redmond, WA, United States of America

Thomas Little