Pepsico, Inc.

Concentrate Manufacturing Company of Ireland

Signal Pharmaceuticals, Inc.

Celgene Corporation

Thomas Lee

Pei K Chang

Glenn Roy

Zena Bell

Hang Chen

Todd A Zaniewski

Ho-Wah Hui

Benjamin Cohen

Jean Xu

Ying Li

Peter S Given

Matthew Michael Kreilein

Anil Menon

William Mutilangi

Sekhar S Surapaneni

Ming J Chen

Nathan Andrew Boersen

William Wei-Hwa Leong

Gino Olcese

Paul Kurtulik

Gregory Yep

Rein Hirs

Darshan Parikh

Laura Nattress

Dora Visky

Ryan May

Xiaozhang Liang

Fari Talebi

Manuel Antonio Arce Garcia

Shawn David Erickson

Christophe Claude Galopin

Kevin Joseph Klopfer

Terrence Joseph Connolly

Juan Antonio Gamboa

Wendy Chan

Stephen Gravina

Winsome Johnson

Amanda Nicole Miklos

Yuliya Kurash

Brenton G Edgar

Helen Curtiss

Robin Berardi

Greg Radko

John Olszewski

Richard Orr

Rashmi Tiwari

Yu-Wen Feng

Ting Wang

Darshan K Parikh

Manuel Antonio Garcia

Ryan Earl May

William Riha

Francis M Finnerty

D-psicose/erythritol compositions comprise, in combination, D-psicose and erythritol as sweeteners together with one or more other edible ingredients. Comestibles are provided, including beverage products and other food products, comprising the novel D-psicose/erythritol compositions. D-psicose and erythritol may each be present in a comestible in a concentration sufficient independently of the other to perceptibly sweeten the composition. An additional sweetener component and other ingredients may be included in the formulation.

Compositions and comestibles

This disclosure provides novel compositions comprising a compound of Formula I. These compositions are useful for improving mouthfeel properties of non-nutritive sweeteners, such as steviol glycosides and blends thereof, in food and beverages containing the same.

Mouthfeel enhancing composition

The present disclosure provides novel sweetener compositions comprising a compound having a structure according to Formula I: wherein R, R, R, and Rare described herein. Also provided are methods of modulating sweetness profile of a product by adding a compound of Formula I to the product, such as a beverage product or a food product. For example, the compound described herein can be added to increase the overall sweetness of a nutritive sweetener sweetened beverages; decrease the sweetness time-of-onset for high potency sweeteners such as rebaudioside A; decreasing bitter, metallic and licorice off-notes of high potency sweeteners; and improve the sweet quality of sweetened products.

Glucosyringic acid analogs as sweetness profile modifiers

The present disclosure provides sweetener compositions, methods of using these compositions, and foods, beverages, and syrups comprising these compositions. The sweetener composition can comprise a sweetener and a sweetness enhancer. The composition can further comprise at least one supplemental sweetness enhancer and/or a salt.

Sweetness enhancer

Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.

Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Natural beverage products and methods for making the same are disclosed. The natural beverage products comprise an acidulant comprising lactic acid and at least one of tartaric and citric acids, optionally other natural carboxylic acids and no phosphoric acid.

Natural beverage products

Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.

Oral dosage forms of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide

Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.

Nanosuspension of a poorly soluble drug via microfluidization process

A method of producing a diet carbonated soft drink comprising combining water and a sweetening amount of Rebaudioside D (Reb D) to produce Reb D sweetened water; injecting carbon dioxide into the Reb D sweetened water to produce carbonated Reb D sweetened water; combining the carbonated Reb D sweetened water with unsweetened syrup to form the diet carbonated soft drink. Alternatively, the method comprises combining water and a sweetening amount of Rebaudioside D (Reb D) to produce Reb D sweetened water; combining the Reb D sweetened water with syrup; injecting carbon dioxide into the combined Reb D sweetened water and syrup to produce the diet carbonated soft drink.

Method of producing Rebaudioside D sweetened diet carbonated soft drinks

Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

[object Object]

Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one

Aspects of the invention relate to beverage compositions, including, for example, concentrated and ready-to-drink formulations sweetened with at least one non-nutritive sweetener and further comprising a bitterant in an amount sufficient to reduce the lingering sweet aftertaste of the non-nutritive sweetener(s). In certain illustrative embodiments, the bitterant comprises gentian. Another aspect of the invention relates to a method that combines a non-nutritive sweetener having a lingering sweet aftertaste with a bitterant to create a mixture such that when the mixture is contained in a beverage, the bitterant is present in an amount sufficient to reduce the lingering sweet aftertaste of the non-nutritive sweetener.

Beverage products with non-nutritive sweetener and bitterant

Growing community of inventors

Scarsdale, NY, United States of America

Thomas Lee