Duke University

Other

Thomas L Ortel

Geoffrey S Ginsburg

Joseph E Lucas

Jen-Tsan Ashley Chi

Deepak Voora

Richard C Becker

William H Kane

Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to antiplatelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.

Diagnostic markers for platelet function and methods of use

Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.

Chimeric blood coagulation proteins are disclosed. The proteins are (i) coagulation factor V in which at least one A3, C1 or C2 domain exon thereof is replaced with the homologous exon of coagulation factor VIII; or (ii) coagulation factor VIII in which at least one A3, C1 or C2 domain exon thereof is replaced with the homologous exon of coagulation factor V. The chimeric proteins are useful for diagnostic purposes in epitope mapping and for therapeutic purposes in facilitating blood coagulations in patients in need of such treatment.

Chimeric blood coagulation proteins

A kit for forming a valve service box (10). The kit includes a plastic service valve housing (24) and a cover box assembly (22). The cover box assembly includes a plastic cover housing (32). Each of the housings (24 and 32) is provided with a cylindrical smooth wall bore (24.21 or 32.21) which may closely receive one end of a length of polyvinyl chloride pipe (26) of an appropriate uniform diameter. The housings (24 and 32) can be bonded by a conventional solvent welding process to the piece of plastic pipe (26) to form the valve service box, the plastic pipe (26) having been cut in the field to be of a correct length.

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Mebane, NC, United States of America

Thomas L Ortel