Apdn (b.v.i.) Inc.

Rafael Pharmaceuticals, Inc.

Apdn, Inc.

Shorr, Robert

Rodriguez, Robert

Boteju, Lakmal

Marecek, James

Bingham, Paul

Kwok, Thomas

Thomas Kwok

Stephane Shu Kin So

Robert G Shorr

Robert J Rodriguez

Ming-Hwa Liang

Paul M Bingham

Lakmal Boteju

James Marecek

Benjamin MingHwa Liang

Robert Rodriguez

Lakmal W Boteju

Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.

Pharmaceutical compounds

This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.

Optical reporter compositions

This invention pertains to methods for authenticating an article comprising tagging the article with light emitting optical reporter particles, and more specifically tagging the articles with up-converting phosphor particles (UCP), linked to nucleic acids of detectable sequence.

Methods for authenticating articles with optical reporters

A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.

Methods for covalent linking of optical reporters

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Thomas Kwok