Lonza Cologne Gmbh

Thomas Koblizek

Timo Gleissner

Herbert Mueller-Hartmann

Andreas Heinze

Andreas Wirth

Herbert Müller-Hartmann

Disclosed is a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes, wherein at least three electrodesare provided, and wherein at least two electrodesare active electrodeswhen the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodesis a potential-free electrodewhen the voltage is applied. Also disclosed is a devicecomprising at least three electrodes, which are connected to at least one voltage source by means of at least one switching device, wherein at least five electrodesare connected to the at least one voltage source by means of four switching devices, wherein at least two electrodesare connected to the voltage source by means of a common switching device. In conjunction with the method described above, the device according to the invention allows the efficient and uniform treatment of adherent cells using an electric field, wherein the switch between active and potential-free electrodes can be carried out quickly and safely using a lower number of switching devices.

Method and device for uniformly treating adherent cells

The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes, wherein at least three electrodesare provided, and wherein at least two electrodesare active electrodeswhen the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodesis a potential-free electrodewhen the voltage is applied. The invention further relates to a devicecomprising at least three electrodes, which are connected to at least one voltage source by means of at least one switching device, wherein at least five electrodesare connected to the at least one voltage source by means of four switching devices, wherein at least two electrodesare connected to the voltage source by means of a common switching device. In conjunction with the method described above, the device according to the invention allows the efficient and uniform treatment of adherent cells using an electric field, wherein the switch between active and potential-free electrodes can be carried out quickly and safely using a lower number of switching devices.

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Goettingen, Germany

Thomas Koblizek