Radiometer Medical Aps

Thomas Kjaer

Thomas Steen Hansen

Hans Peter Blaabjerg Jakobsen

Lydia Dahl Clausen

Poul Ravn Sorensen

Lone Michelsen

Thomas Pedersen Nygaard

Christian Strange

Willy Lindegaard Andersen

Jens Østergaard

Tina Kristensen

Thomas Pedersen Nyggard

Paul Ravn Soerensen

A sensor element for detecting an analyte in a fluid sample by optical probing comprises a translucent membrane with a front side defining a sensor surface for contacting a fluid sample, and a back side facing away from the front side. The sensor element has a reflective layer at the front side of the translucent membrane. An optical input port and an optical output port are connected to the back side of the translucent membrane. The sensor element further comprises an optical constriction element with a screen element arranged between the input port and the output port. The constriction element further comprises a reflective element arranged at the backside of the translucent membrane and facing towards the reflective layer, thereby defining a probing region, the probing region comprising pores extending from respective openings at the sensor surface into the translucent membrane.

Porous membrane sensor element

There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes () in a liquid () comprising a translucent element comprising pores (), wherein the pores () are dead end pores () extending into the translucent element from respective openings () in the translucent element, wherein a cross-sectional dimension of the openings () of the pores () is dimensioned so as to prevent larger particles or debris from entering the pores (), while allowing the analyte or the group of analytes in the liquid () to enter the pores () via diffusion, one or more light sources () being adapted to illuminate at least the pores () in the translucent element (), and a light detector () being adapted to at each of multiple points in time receive light () emerging from the pores () in response to illumination (I I) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.

Determining time response value of an analyte in a liquid

There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes () in a liquid () comprising a translucent element comprising pores (), wherein the pores () are dead end pores () extending into the translucent element from respective openings () in the translucent element, wherein a cross-sectional dimension of the openings () of the pores () is dimensioned so as to prevent larger particles or debris from entering the pores (), while allowing the analyte or the group of analytes in the liquid () to enter the pores () via diffusion, one or more light sources () being adapted to illuminate at least the pores () in the translucent element (), and a light detector () being adapted to at each of multiple points in time receive light () emerging from the pores () in response to illumination () by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.

The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space. The sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space.

Porous membrane sensor assembly

The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g. selected from a calcium-selective ionophore, a potassium-selective ionophore, and a sodium-selective ionophore), and wherein the first ionophore is not present in any ion-selective electrode in the sensor array other than in the first ion-selective electrode.

Mixed ionophore ion-selective electrode for the improved dectection of urea in blood

A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Method for calibrating a device for measuring the concentration of creatinine

A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

The invention relates to a porous optical fiber for the detection of an analyte in a fluid by optical probing. The optical fiber has a first end and a second end opposite to the first end, as seen in a longitudinal direction, and a circumferential surface delimiting the optical fiber in radial directions perpendicular to the longitudinal direction. The optical fiber comprises a core adapted for supporting at least one optical mode propagating in the longitudinal direction, the core having a circumferential interface delimiting the core in the radial directions. The optical fiber further comprises pores penetrating from an opening at the circumferential surface through the circumferential interface into the core of the optical fiber, wherein a cross-sectional dimension of the openings is dimensioned so as to prevent a particulate fraction of the fluid from entering the pores, while allowing the analyte to enter the pores.

Porous optical fiber for the detection of an analyte in a fluid

The present application discloses a planar enzyme sensor for measuring the concentration of an analyte in a solution comprising a substrate of an electrically insulating material supporting an electrode layer of an electrically conductive material. The substrate and electrode layer have a plurality of layers disposed thereon which include an enzyme layer and a microporous outer layer covering the enzyme layer, wherein the outer layer comprises a continuous phase of a water-resistant polymer (e.g. a polyvinylacetate or an acrylate copolymer), a protein (e.g. an enzyme) embedded in the continuous phase, and possibly polytetrafluoroethylene particles. The enzyme and the polytetrafluoroethylene particles provide a controlled porosity to the outer membrane.

Outer layer for enzyme sensors

A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the method comprising: determining sensitivities of the device for each of two or more calibration solutions, wherein each calibration solution has a different amount of enzyme modulator; determining a degree of modulation for each of the two or more calibration solutions; determining a degree of modulation for a sample to be measured; and calculating the sensitivity of the device for the sample, wherein said calculating comprises modifying the sensitivity of one of the two or more calibration solutions by a function comprising the determined degrees of modulation.

Calibration concept for amperometric creatinine sensor correcting for endogenous modulators

Mixed ionophore ion-selective electrode for the improved detection of urea in blood

Sensor for the optical detection of free hemoglobin () in a whole blood sample (), the sensor comprising a translucent slab () with a front side () and a back side () facing away from the front side (), wherein the front side () is adapted for being contacted with a whole blood sample (); a reflective layer () at the front side () of the translucent slab (), the reflective layer () being adapted to reflect light reaching the reflective layer () from the translucent slab (); an optical probing device comprising a light source () and a detector (), wherein the light source () is adapted to illuminate at least pores in the translucent slab, wherein the detector () is arranged to receive light () emerging from the pores () in response to an illumination () by the light source (), and wherein the detector () is adapted to generate a signal representative of the detected light. The translucent slab () is provided with dead-end pores () extending from the front side () into the translucent slab () in a direction towards the backside (). Each of the pores () has a respective opening () in the front side () of the translucent slab () penetrating the reflecting layer (). A cross-sectional dimension of the openings () of the pores () is dimensioned so as to prevent red blood cells () from entering the pores (), while allowing free hemoglobin () to enter the pores ().

Optical sensor for detection of free hemoglobin in a whole blood sample

A porous mirror () for detection of an analyte () in a fluid () by optical probing, comprising a translucent slab () with a front side (), and a backside () facing away from the front side (), wherein the front side () is adapted for being contacted with a fluid (), and a reflective layer () at the front side () of the translucent slab (), the reflective layer () being adapted to reflect light reaching the reflective layer from the backside () of the translucent slab (), wherein the translucent slab () comprises pores (), wherein the pores () are dead end pores () extending from respective openings () at the front side () into the translucent slab (), through the reflective layer (), wherein a cross-sectional dimension of the openings () of the pores () is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (), while allowing the analyte () in the fluid () to enter the pores () via diffusion.

Porous mirror for optical detection of an analyte in a fluid

The present disclosure relates to an improved enzyme sensor comprising a cover membrane layer of a porous polymeric material, the outer surface and pore mouths of at least one face of the porous polymeric material being covered by a hydrophilic polymer. The sensor is useful determining the presence or amount of biological analytes, e.g., glucose, lactate, creatine, creatinine, etc.

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Smoerum, Denmark

Thomas Kjaer