Sanofi-A Ventis Deutschland Gmbh

Roche Diagnostics Gmbh

Aventis Pharma Deutschland, Gmbh

Hoechstaktiengesellschaft

Novartis Ag

Thomas Kissel

Hans-Harald Sedlacek

Hans-Dieter Klenk

Gerhard Winter

Hans Koll

Rolf Muller

Rolf M&uuml;ller

Hans-Peter Elsässer

Michael Morlock

Thorsten Bieber

Dagmar Fischer

Holger Petersen

Nina Seidel

Thomas Renette

The invention relates to low molecular weight polyethylenimines, to vectors for inserting nucleic acids into cells which contain low molecular weight polyethylenimines, and to the preparation and use of the low molecular weight polyethylenimine and the vector. The invention relates to a vector for inserting a nucleic acid into a cell, which vector contains a low molecular weight polyethylenimine (LMW PEI) and a nucleic acid, with the LMW PEI having a molecular weight of less than 50,000 Da.

Biologically tolerated low molecular weight polyethylenimines

Target cell-specific non-viral vectors for inserting genes into cells, pharmaceutical compositions comprising such vectors and their use

The invention concerns parenteral pharmaceutical forms of administration containing polypeptide in the form of microparticles and a process for the production thereof. The microparticles according to the invention contain as a biodegradable polymer an ABA triblock copolymer the A block of which is a copolymer of lactic and glycolic acid and the B block of which represents a polyethylene glycol chain, together with additives that are selected from the group comprising serum proteins, polyamino acids, cyclodextrins, cyclodextrin derivatives, saccharides, amino sugars, amino acids, detergents or carboxylic acids as well as mixtures of these additives. The microparticles according to the invention continuously release the polypeptide over a relatively long time period even when the amounts of polypeptide they include are small or susceptible to aggregation.

Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof

Target cell-specific, non-viral vectors for inserting genes into cells, pharmaceuticals composition comprising such vectors, and methods of their use. Target cell-specific, non-viral vectors for inserting at least one gene into cells of an organism, comprising a complex comprising the following components:

Target cell-specific non-viral vectors for inserting genes into cells,

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Marburg, Germany

Thomas Kissel