Curevac Ag

Curevac Manufacturing Gmbh

Curevac Real Estate Gmbh

Curevac Se

Curevac Gmbh

Universitätsklinikum Schleswig-Holstein

Thomas Ketterer

Thorsten Mutzke

Stefanie Sewing

Michael Wiggenhorn

Florian Von Der Mülbe

Tilmann Roos

Benyamin Yazdan Panah

Fabian Johannes Eber

Michael Sonntag

Katharina Kolland

Andreas Funkner

Norbert Broghammer

Stefanie Dorner

Johannes Kamm

Jochen Probst

Ladislaus Reidel

Steve Pascolo

Frank Schaubhut

Lilia Gontcharova

Susanne Bauer

Andreas Schmid

Ingmar Hoerr

Aniela Wochner

Ernst Bayer

Holger Kalthoff

Michael Gerster

Stefanie Sewig

Birgit Scheel

Inge Bayer, Legal Representative

Hendrik Ungefroren

Alexander Fiedler

Florian Von Der MÜLBE

Florian Von Der Muelbe

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

Dry powder composition comprising long-chain RNA

The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).

Method for producing and purifying RNA, comprising at least one step of tangential flow filtration

The present invention is directed to the field of RNA formulation, in particular to lyophilization of RNA. The invention provides a method for lyophilization of RNA. The present invention further concerns a lyophilized composition obtainable by the inventive method, a pharmaceutical composition, a vaccine and a kit or kit of parts. Moreover, the present invention provides a novel use of a lyoprotectant for lyophilizing RNA, the use of the inventive method in the manufacture of a medicament as well as the first and second medical use of the composition obtainable by the inventive method, the pharmaceutical composition, the vaccine or the kit or kit of parts according to the invention.

Lyophilization of RNA

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

The present invention relates to a method for producing RNA. In particular, the present invention relates to a method for producing RNA, which is scalable and provides RNA at a high purity. The present invention provides a method for producing RNA under GMP and/or cGMP-compliant conditions. The invention further provides specific processes for use as a quality control in the manufacturing of a template DNA and/or in a method for producing RNA, in particular by in vitro transcription.

Method for producing RNA

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Gomaringen, Germany

Thomas Ketterer