Basf Aktiengesellschaft

Abbvie Inc.

Abbvie Deutschland Gmbh and Co Kg

Basf Corporation

Basell Polyolefine Gmbh

Basf Se Corporation

Abbott Laboratories Corporation

Abbott Gmbh & Co Kg

Thomas Kessler

Bernd Liepold

Jonathan Miller

Charles F Helms, Jr

Yi Gao

Eric Allen Schmitt

Jörg Breitenbach

Jurgen Hofmann

Dominick A Burlone

Joerg Breitenbach

J&uuml;rgen Hofmann

Yi Shi

Walter Gotz

Carl M Knable

Ping Gao

Nancy E Sever

John B Morris

Mark Costello

Harald Krull

Peter Hoelig

Mirko Pauli

Drazen Kostelac

Rajeev Gokhale

Herman Brandt

James L Huff

Anna Moosmann

Fatih Durak

Karin Rosenblatt

Roland Ettl

Joerg Rosenberg

Gunther Berndl

Jörg Rosenberg

Josef Wunsch

Armin Lange

Christoph Schmidt

Andreas Ernst

Matthias Degenhardt

Siegfried Strathmann

Klaus Schelberger

Andreas Deckers

Terrence B Mazer

Bernd Lothar Marczinke

Rainer Dyllick-Brenzinger

Matthias Bratz

Wolfgang Rohde

Ekkehard Jahns

David Fischer

Karl-Heinrich Schneider

Paulus De Lange

Soumojeet Ghosh

J&ouml;rg Breitenbach

Sibylle Brosius

Martin Lux

Norbert Guentherberg

Hans-Peter Harz

Stephan Kothrade

Ulrich Reinhold

Torsten Freund

Werner Maier

Kevin Novak

Manfred Winter

Andreas Kleinke

Karl-Heinz Fauth

Normanella Dewille

Roland Betz

Ulrich Westedt

Peter Wittmer

Didier Lefebvre

Markus Mägerlein

Markus Maegerlein

Wolfgang Heinzl

Guenther Grimm

Susan George

Thomas Bl&uuml;mel

Claudia Packhaeuser

Franz-Josef Sch&ouml;ner

Claudia Henzel

Bryan Wiesner

Youngsuk Heo

Claudia Packhäuser

Gary Katz

Douglas Wearly

Eik-Lang Lau

Gunther Grimm

Günther Grimm

The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.

Solid antiviral dosage forms

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (), each of the shafts () carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element () which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.

Process for producing a solid dispersion of an active ingredient

A pharmaceutical dosage form comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric binder composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer, wherein at least 95% by weight of the vinylpyrrolidone homopolymer has a molecular weight distribution within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000. The dosage form is preferably prepared by a melt extrusion process. The polymeric carrier composition exhibits a high drug dissolution power and allows a reduction of the viscosity of the melt without deteriorating the mechanical properties and storage stability of the dosage form.

Pharmaceutical dosage form comprising polymeric carrier composition

The present invention relates to a process for producing monolithic tablets. The method employs a melt-processed composition containing at least on active agent and at least one thermoplastic binder. The invention further relates to a method for cutting and deflashing a belt of pre-shaped bodies of a melt-processed composition, wherein the pre-shaped bodies are interconnected by flash.

Method for producing monolithic tablets

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (), each of the shafts () carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element () that is derived from a screw type element (FIG.).

Solid mixtures of a reactive size and starch, which are obtainable by mixing at least one reactive size with at least one starch in a melt in the presence of at least one destructuring agent for starch under the action of shear forces at from 65 to 250&#xb0; C. and cooling the melt to room temperature, are used in the form of aqueous dispersions as process assistants in papermaking.

Mixtures of solids, consisting of a reactive sizing agent and starch, method for producing said mixtures and use thereof

Alkylketene dimers are prepared by reacting acyl chlorides with tertiary amines in a molar ratio of from 1:1 to 1:1.6 at from 65 to 150&#xb0; C. and with a residence time of from 1 to 30 minutes in the absence of solvents with thorough mixing and isolation of the alkylketene dimers.

Method for producing alkylketen dimers

A process for producing pellets comprising biologically active substances in which the biologically active substances are homogeneously dispersed in a matrix based on at least one thermoplastic polymer, which polymer has in aqueous medium a pH-dependent solubility, by homogeneous mixing of the starting materials in the melt and subsequent extrusion and shaping, which comprises the shaping being performed in a cooling medium in which the pellets are not soluble or dispersible.

Underwater or under-hydrocarbon pelletizing of biologically-active-compound-containing melts

Bimodal polyethylene blends are made from a high-molecular-weight ethylene copolymer and a low-molecular-weight ethylene homo- or copolymer and have a melt flow rate MFR 190/21.6 of from 6 to 14 g/10 min, a density of from 0.94 to 0.97 g/cm , an environmental-stress-cracking resistance ESCR>150 h and a value of less than 3 when the quality of blending in the blend is measured to ISO 13949. A process prepares polyethylene blends of this type by melting and homogenization in a mixing apparatus and discharge via a gear pump. The blends are used to produce moldings, in particular hollow articles and pressure pipes.

High mixture-quality bi-modal polyethylene blends

Retarding formulations of active substances used for plant protection

The invention relates to a method for producing granulates which contain enzymes and which are suited for feeding animals. The granulates are produced by mixing at least one enzyme with a supporting material and by extruding this mixture. The inventive method is characterized in that the supporting material is firstly plasticized in a screw mixer which is equipped with at least one horizontally arranged screw. Afterwards, the enzyme is introduced into the screw mixer and is processed with the plasticized supporting material to produce a homogeneous material which is then extruded.

Process for producing enzyme-containing granules

This invention provides an apparatus and method for injecting an additive directly into a polymer melt stream. The method comprises supplying a melt flow of a polymeric host material to a die assembly having a thin-plate assembly and injecting at least one additive into at least one predetermined location in a cross-section of the melt flow of the polymeric host material while the melt flow passes through the die assembly. The method achieves uniform dosing of the one or more additives in the extrusion direction in the polymeric host material without homogeneously mixing the one or more additives and the polymeric host material. The apparatus for directly injecting one or more additives into a polymer melt stream comprises a pumping system, a die assembly having a thin-plate assembly, and a distribution line.

Apparatus and method for direct injection of additives into a polymer melt stream

A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.

Process for producing solid dosage forms

Growing community of inventors

Schifferstadt, Germany

Thomas Kessler