Agency for Science, Technology and Research

Thomas Joseph

David Philip Lane

Chandra Shekhar Verma

Christopher John Brown

Yaw Sing Tan

Fernando Jose Ferrer Gago

The present invention relates to non-membrane disruptive and p53 activating stapled peptides, as well as methods of treatment of cancer involving the use of these peptides. In one embodiment, the peptide comprises or consist of the amino acid sequence of TSFXaaEY-WXaaLLXaa, where Xaais (R)-2-(7'-octenyl)alanine or derivative thereof, or is (R)-2-(4&#x2032;-pentenyl)alanine or derivative thereof; and Xaaand Xaaare independently any type of amino acid or modified amino acid. In another embodiment, the peptide comprising or consisting of the amino acid sequence of TSFXaaEYW XaaLLXaaENXaa, wherein Xaaand Xaaare any type of amino acid or modified amino acid; Xaais S, or P, or (S)-2-(4&#x2032;-pentenyl)alanine or a derivative of (S)-2-(4&#x2032;-pentenyl)alanine; and wherein Xaais F or Y.

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Singapore, Singapore

Thomas Joseph