General Electric Company

Other

Sloan-kettering Institute for Cancer Research

Thomas Joseph Kelly

Michael James Weimer

Bernard Patrick Bewlay

Hakim Djaballah

Mark G Frattini

Mohamed Rahmane

Michael Francis Xavier Gigliotti

Curtiss Mitchell Austin

Sairam Sundaram

John H Snyder

Stephen Francis Rutkowski

Michael Francis Xavier Gigliotti, Jr

Russell W Smashey

Ronald L Sheranko

Shyh-Chin Huang

Nripendra Nath Das

Wayne Ray Grady

Bhupendra Kumar Gupta

Stephen Craig Mitchell

Harvey M Maclin

Charles Robert Wojciechowski

Gary D Mercer

Robert Dale Lawrence

Richard Ravenhall

Keith B Alexander

Rabon Hensley

Troy Lance Finton

Kenneth Eric Lutz

Melvin A Schobert

Melvin Robert Jackson

Brian Ellis

Stephen Joseph Ferrigno

Charles Gitahi Mukira

Richard John Grylls

Mark Alan Rosenzweig

Christine Govern

Howard John Farr

Glenn Herbert Nichols

Jerry Donald Schell

Lyle Timothy Rasch

Earl Claude Helder

Edward John Emilianowicz

Randall Charles Bauer

P Kennard Wright, Iii

Robert E Allen

Brent Ross Tholke

Paul J Monson

Philemon Kennard Wright, Iii

Eva Zielonka Lanman

Marek M Steplewski

Paul John Fink

Joseph G Sabato

D Keith Patrick

William Henry Harrison

Joseph Carl Wukusick

Eric J Boerger

Warren D Grossklaus

Bernard Patrick Bewley

Mark David Veliz

Samuel Frank Mastrorocco

Vallerie Althea McGee

Christine Walston

Patricia S A Bezerra

Christine Govern Walston

Dean A Wheeler

Donald E Larson, Jr

Blair London

Trucee V Kelly

Richard Kenneth Whitacre

Joseph Giancarlo Sabato

Glenn H Nichols

Jr Michael Francis Xavier Gigliotti

Brian Michael Ellis

Jr William Thomas Carter

Michael Patrick Maly

Melissa J Parks

The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.

CDC7 kinase inhibitors and uses thereof

Cdc7 kinase inhibitors and uses thereof

Gamma titanium aluminide intermetallic compositions (gamma TiAl intermetallics) based on the TiAl (gamma) intermetallic compound. The gamma TiAl intermetallics contain chromium and niobium, as well as controlled amounts of carbon that achieve a desirable balance in room temperature mechanical properties and high temperature creep capabilities at temperatures approaching and possibly exceeding 1600&#xb0; F. (about 870&#xb0; C.).

Titanium aluminide intermetallic compositions

The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B) or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.

A method for manufacturing a turbine damper by a metal injection molding process is disclosed. The damper includes a base section and a wire section, and is formed of a nickel-base or cobalt base superalloy.

Monolithic and bi-metallic turbine blade dampers and method of manufacture

Methods for making a reinforced refractory crucible for melting titanium alloys including providing a form, applying a facecoat to the form, the facecoat having at least one facecoat layer, applying a backing about the facecoat, the backing having at least one backing layer, applying at least one reinforcing element to at least a portion of the facecoat layer, the backing layer, or a combination thereof where the reinforcing element includes at least one composition selected from ceramic compositions, metallic compositions, and combinations thereof.

Methods for making reinforced refractory crucibles for melting titanium alloys

A method for preparing a filler-metal weld rod of a filler-metal composition includes the steps of centerless grinding the filler metal weld rod of a forced mixture of a mass of titanium aluminide intermetallic alloy powder that was used to form the weld rod, and hot isostatic pressing the filler-metal weld rod at a temperature greater than 2150&#xb0; F., at a pressure between about 15,000 pounds per square inch and about 25,000 pounds per square inch and for a time of about 1 to 5 hours, thereby increasing the relative density to between about 98% and about 99%.

Preparation of filler-metal weld rod by injection molding of powder

Refractory crucibles capable of managing thermal stress and suitable for melting highly reactive alloys having a facecoat, a backing, and at least one retaining ring applied about at least a portion of the backing of the crucible, the retaining ring comprising a composition selected from the group consisting of conductive materials, non-conductive materials, and combinations thereof.

Refractory crucibles capable of managing thermal stress and suitable for melting highly reactive alloys

Crucibles for melting titanium alloys having a facecoat including at least one facecoat layer containing an oxide selected from scandium oxide, yttrium oxide, hafnium oxide, a lanthanide series oxide, and combinations thereof, and a backing including at least one backing layer where the crucible has a backing to facecoat thickness ratio of from about 6.5:1 to about 20:1.

Crucibles for melting titanium alloys

A filler-metal weld rod of a filler-metal composition is prepared by providing a mass of metallic powders, mixing the metallic powders with a temporary thermoplastic binder to form an injection-moldable mixture, and thereafter injection molding the injection-moldable mixture at an injection-molding temperature above the thermoplastic temperature of the thermoplastic binder to form an injection-molded rod. Any excess thermoplastic binder is removed from the injection-molded rod, and the injection-molded rod is thereafter sintered to form a filler-metal weld rod, with the temporary thermoplastic binder removed in the step of sintering.

Reinforced crucibles for melting titanium alloys having a facecoat including at least one facecoat layer, a backing including at least one backing layer, and at least one reinforcing element applied to at least a portion of one or more of the facecoat layer, the backing layer, or a combination thereof where the reinforcing element includes at least one composition selected from ceramic compositions, metallic compositions, and combinations thereof.

Reinforced refractory crucibles for melting titanium alloys

Growing community of inventors

Cincinnati, OH, United States of America

Thomas Joseph Kelly