Smithkline Beecham Corporation

Thomas Joseph Carr

Daniel F Veber

Timothy Francis Gallagher

Scott Kevin Thompson

Dennis Shinji Yamashita

Stacie Marie Halbert

Renee Louise DesJarlais

Hye-Ja Oh

Jack Hwekwo Yen

Dashyant Dhanak

Peter Lawrence DeMarsh

Geoffrey Bainbridge Dreyer

Ashley Edward Fenwick

Novel anti-infective and methods of using them are provided.

Anti-infectives

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Protease inhibitors

The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.

Retroviral protease inhibitors

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Phoenixville, PA, United States of America

Thomas Joseph Carr