Novartis Ag

Novartis Pharma Gmbh

Thomas Josef Troxler

Yves Auberson

Nichola Smith

Robert Alexander Pulz

Mahbub Ahmed

Lisa Ann Rooney

Anne-Marie Edwards

Konstanze Hurth

Mark G Bock

Piotr Henryk Karpinski

Dario Braga

Roger John Taylor

David Andrew Sandham

Kamlesh Jagdis Bala

Stephanie Kay Dodd

Duncan Shaw

Stefano Luca Giaffreda

Xiaoyang Wang

David William Porter

James Dale

Xuechun Zhang

Ralf Glatthar

Marco Curzi

Andrew Brearley

Daniel Hoyer

Jessica Louise Taylor

Joe Wrigglesworth

Tie-Lin Wang

Dominik Feuerbach

Marina Tintelnot-Blomley

Siem Jacob Veenstra

Claudia Betschart

Mathias Frederiksen

Bernard Lucien Roy

Werner Müller

Haiyang Jiang

Gideon Shapiro

Stefanie Flohr

Rainer Machauer

Peter Neumann

Oliver Simic

Joachim Nozulak

Eric Vangrevelinghe

Thomas Zoller

Max Peter Seiler

Kurt Laumen

Anne-Marie D'Souza

Daniel Berney

Hayang Jiang

Tielin Wang

Robin Breckenridge

Anne-Marie D'souza

Mark Gary Bock

David Porter

Ann-Marie D'SOUZA

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Carboxamide derivatives

The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

Carbamate/urea derivatives

The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. Formula (I), wherein A represents O or N(R); Y represents a group of formula, or wherein the left bond is attached to the A group and the right bond is attached to the R group; R represents a substituted or unsubstituted C-C, substituted or unsubstituted hetero-C-Caryl, a group N(R)(R), or a group N(R)(CHPR); R represent a hydrogen, C-Calkyl, or CF; Rrepresents hydrogen, C-Calkyl, or CF; Rrepresents hydrogen, C-Calkyl, or CF; Rrepresents a substituted or unsubstituted C-Caryl or a substituted or unsubstituted C-Cheteroaryl; in free base or acid addition salt form. 

1-aza-bicyclo[3.3.1]nonanes

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Compound of the formula (I) wherein R, R, n and m are as defined in the specification. The compounds of formula (I) are somatostatin sst1 receptor antagonists. 

Substituted piperidine derivatives as somatostatin SST1 receptor antagonists

The invention provides compounds of formula (I) wherein

Acetylene derivatives

The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula I.

Dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof

The present invention relates to novel macrocyclic compounds of the formula wherein R, R, R, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Macrocyclic lactams and pharmaceutical use thereof

The invention provides compounds of formula () wherein X, Rand Rare as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety and bipolar disorders.

Piperazine derivatives having SST1 antagonistic activity

Growing community of inventors

Wahlen b. Laufen, Switzerland

Thomas Josef Troxler