Abbott Laboratories Corporation

Thomas John Perun

Bruce W Horrom

Ronald R Rasmussen

James B McAlpine

Ronald E Carney

Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-deoxyseldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.

Seldomycin factor 5 derivative

This invention provides 2,4-diamino-5-benzylpyrimidines represented by the formula ##STR1## wherein R.sub.1 is H or loweralkyl; R.sub.2 is H, loweralkyl or R.sub.3 CO-- wherein R.sub.3 is H, alkyl, or cycloalkyl-lowerakyl; and X is a halogen; and the acid addition salts thereof. These pyrimidine compounds are useful as antibacterial agents, and as potentiators of the anti-bacterial activity of sulfonamides.

2,4-Diamino-5-benzylpyrimidines

This invention provides 2,4-diamino-5-benzylpyrimidines represented by the formula ##STR1## wherein R.sub.1 is H or loweralkyl; R.sub.2 is H, loweralkyl or R.sub.3 CO-- wherein R.sub.3 is H, alkyl, or cycloalkyl-loweralkyl; and X is a halogen; and the acid addition salts thereof. These pyrimidine compounds are useful as antibacterial agents, and as potentiators of the antibacterial activity of sulfonamides.

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Libertyville, IL, United States of America

Thomas John Perun