Koninklijke Philips Corporation N.v.

Thomas Johannes Van Gijsel

Mark Thomas Johnson

Toon Hendrik Evers

Stefan Johannes Hendrikus Toonen

Eduard Gerard Marie Pelssers

Lutz Christian Gerhardt

Kiran Hamilton J Dellimore

Lucas Johannes Anna Maria Beckers

Willem-Jan Arend De Wijs

Ron Martinus Laurentius Van Lieshout

Susanne Maaike Valster

Matthias Irmscher

Marlieke Joan Overdijk

Job Lipsch

Harma Martine Feitsma

Wilbert Hendrik Bouwman

Eveline Catharina Anna Clasina Den Biezen-Timmermans

Sergei Y Shulepov

Provided is a method of determining a concentration (C) of a first analyte (a) in sweat excreted by a first sweat gland type at a first skin location (i) having the first sweat gland type and a second sweat gland type. The method comprises measuring a first concentration (I) of the first analyte in sweat excreted at the first skin location and measuring at least one parameter of sweat excreted by the second sweat gland type at a second skin location (ii) having the second sweat gland type but not the first sweat gland type. The at least one parameter is used to determine a dilution factor (II) which quantifies dilution of the first analyte by sweat excreted by the second sweat gland type at the first skin location. This dilution factor (II) is then used to correct the first concentration (I) so as to determine the concentration (C). Further provided is an apparatus () for determining the concentration (C).

Method and apparatus for differential sweat measurement

A device is provided comprising a receiving chamber for receiving a patient's sample, a first reagent reservoir and a second reagent reservoir. The receiving chamber may be configured for receiving at least an end portion of a sample collecting element, with the patient's sample being collected by that sample collecting element. The first reagent reservoir may generally be configured to accommodate a liquid reagent which may include a lysing agent, i.e. the liquid may be a kind of a lysis buffer. Likewise, the second reagent reservoir may generally be configured to accommodate a dry reagent which may include magnetic particles. The device may further comprise at least one of the following two actuators, a first actuator for supplying a first reagent from the first reagent reservoir to the sample and a second actuator for supplying a second reagent from the second reagent reservoir to the resulting mixture.

System for preparing a sample

In order to provide a system allowing an improved and facilitated preparation of a sample for an appropriate analysis, a device for preparing a patient's sample before analysis is provided. The device comprises a housing () and an actuator (). The housing includes a receiving chamber (). The receiving chamber is configured for receiving a liquid. The actuator is movable relative to the housing. The actuator is configured for extracting a predetermined amount of the liquid received in the receiving chamber and for supplying the extracted liquid to a reagent chamber, so that the reagent is suspended in the liquid. The actuator comprises a metering chamber () configured for receiving the predetermined amount of the liquid and for supplying the predetermined amount of the liquid to the reagent chamber.

System for applying a reagent to a sample

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Helmond, Netherlands

Thomas Johannes Van Gijsel