Pharmacopeia Drug Discovery, Inc.

Techelan, LLC

Thomas James Hatcher

Aleksandr Grinberg

Ilya Feygin

Joseph J Brzezinski

A particle sorter/dispenser wherein particles that are suspended in a liquid are flowed through a conduit and selectively dispensed through a dispensing orifice. The conduit includes a sensing zone wherein the liquid-suspended particles are interrogated by a sensor. Data from the sensor is received by processing electronics that analyzes the data from the sensor and makes a decision whether or not to dispense a particle. The particle sorter/dispenser further includes a switch that, responsive to a signal from the processing electronics, controls whether or not a given particle is dispensed through the dispensing orifice. The switch has one or two valves that introduce relatively high-pressure liquid into the conduit. The flow streamlines of the high-pressure liquid controls the flow of the relatively low-pressure liquid-suspended particles in the conduit. Particles that are not dispensed are flowed past the dispensing orifice to a recycle reservoir that depends from the downstream end of the conduit.

Apparatus comprising a particle sorter/dispenser and method therefor

A single channel reformatter having a syringe that is movable along a z-axis by a z-positioner. A x-y positioner is capable of positioning any well of a source plate having a plurality of wells, and of positioning any well of a destination plate having a plurality of wells, beneath the syringe. Liquid from a well of the source plate is aspirated by the syringe and dispensed into one or more wells of the destination plate. Since the syringe does not move in the x-y plane, it is advantageously integrated into a wash system that cleanses it between liquid transfer operations. The drive element that actuates the syringe to aspirate and dispense during liquid transfer operations is advantageously used to drive the wash cycle. In a method according to present invention for controlling the reformatting operation, well-to-well links are specified, a preferred execution order for executing the specified links is determined, and the specified links are executed in the preferred order.

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Burlington Township, NJ, United States of America

Thomas James Hatcher