Boehringer Ingelheim Pharmaceuticals, Inc.

Ontogen Corporation

Thomas James Baiga

Edmund J Moran

Romaine R Maiefski

Gregory Paul Roth

Roy Lewis Barr

Junefredo Fajardo Apon

Steven Russell Bush

Disclosed is an apparatus for automated synthesis containing a shaker deck with a plurality of reaction blocks containing a plurality of reaction wells, an arm containing an array of extending units capable of actuating physical steps along a plurality of axes of each reaction block, each reaction block being situated on a turntable, each turntable being further capable of rotating the reaction block along a central axis. Also disclosed are methods of preparing a peptide, oligonucleotide an small molecules using the apparatus.

Apparatus for automated synthesis

A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for the synthesis supports; means for contacting each array of synthesis supports with a different monomer to provide a first chemical transformation of the synthesis supports; a second plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for receiving the chemically transformed synthesis supports contained in the first plurality of support carriers; transfer apparatus for transferring a selected row or column of synthesis supports from each of the first plurality of carriers to each of the second plurality of carriers to enable the supports in the second to undergo at least a second chemical transformation; and whereby each support position in each carrier identifies the chemical compound thereon.

Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports

Growing community of inventors

Oceanside, CA, United States of America

Thomas James Baiga