Abbott Laboratories Corporation

Bristol-myers Squibb Compnay

Other

Thomas J Sowin

Hing L Sham

Daniel W Norbeck

Daniel S Reno

Anthony Ralph Haight

Chen Zhao

Michael S Allen

Timothy L Stuk

Dale J Kempf

Howard E Morton

Jien-Heh J Tien

Steven M Hannick

Linda M Lijewski

M Robert Leanna

Richard J Pariza

Laura Melcher

Nan-Horng Lin

Timothy A Robbins

Francis A Kerdesky

Denton C Langridge

David Scarpetti

Elizabeth M Doherty

Le Wang

Zhi-Fu Tao

Gerard M Sullivan

Yunsong Tong

Jill E Hochlowski

Gaoquan Li

Laura A Hexamer

Rolf E Swenson

Magdalena Przytulinska

Anne-Laure Marie Grillot

Jacob J Plattner

Thomas Dale Penning

Takahiro Sato

Takayuki Suzuki

Stevan Wakefield Djuric

Julie M Miyashiro

Anil Vasudevan

Lisa A Hasvold

Terry J Rosen

Keith W Woods

Vincent L Giranda

Henry Q Zhang

Zhiren Xia

Akiyo K Claiborne

Robert Bruce Diebold

Ping Xia

David L Garmaise

Arthur J Copper

David N Whittern

Warren S Wade

Compounds of formula (I) where X, C, and Dare defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Heterocyclic kinase inhibitors

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Fused tri and tetra-cyclic pyrazole kinase inhibitors

Macrocyclic kinase inhibitors

Retroviral protease inhibiting compounds

The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.

Attached tags for use in combinatorial chemistry synthesis

The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching &ldquo;tags&rdquo; that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.

Coding combinatorial libraries with fluorine tags

A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.

Intermediate for making retroviral protease inhibiting compounds

Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R.sub.6 and R.sub.7 are each hydrogen or R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl or benzyl; or R.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R.sub.8 is hydrogen or --C(O)R' wherein R' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

Process for the preparation of a disubstituted

Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane

Growing community of inventors

Grayslake, IL, United States of America

Thomas J Sowin