Novartis Vaccines & Diagnostics, Gmbh

Universaity of Stellenbosch

Thomas J Scriba

Susan Barnett

Jan Zur Megede

Ying Lian

Susan Engelbrecht

Estrelita Janse Van Rensburg

Estrelita Janse Van Rensberg

The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polypeptides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

HIV-1 south african subtype C env proteins

The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.

Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2

Growing community of inventors

Oxford, United Kingdom

Thomas J Scriba