3m Innovative Properties Company

Blanchette Rockefeller Neurosciences Institute

Synaptogenix, Inc.

Cognitive Research Enterprises, Inc.

West Virginia University

Alkon, Daniel L.

Nelson, Thomas J.

Thomas J Nelson

Aaron K Nienaber

Joseph B Eckel

Daniel L Alkon

Brant A Moegenburg

Thomas P Hanschen

Steven J Keipert

Eric M Moore

Ann M Hawkins

Amelia W Koenig

Jaime A Martinez

Louis S Moren

Ronald David Jesme

Mark A Lukowski

Ronald Wayne Ausen

Negus B Adefris

Ernest L Thurber

Stephen M Sanocki

Brian D Goers

John M Brandner

Thomas J Anderson

Samad Javid

Gregory P Sorenson

Naiyong Jing

Albert I Everaerts

Scott R Culler

Mahfuza B Ali

Edward J Woo

Dwight D Erickson

John T Boden

Ilya Gorodisher

Nathan E Schultz

Kathleen S Shafer

Badri Veeraraghavan

Corinne Elizabeth Lipscomb

Tien T Wu

Brian G Koethe

Maiken Givot

Fay T Salmon

Cyrus A Anderson

Junting Li

Geoffrey I Wilson

Erin D Spring

Rebecca A Putans

Don Vincent West

Scott W Peterson

Robinette S Alkhas

Vincent R Jansen

Wayne W Maurer

Jon P Nietfeld

Myhanh T Truong

Adam D Miller

Gerry A Hoffdahl

Jing Zhang

Jasmeet Kaur

Taisiya Skorina

Melissa C Schillo-Armstrong

Daniel M Lentz

Grayce T Huberty

Alessandro Quattrone

Miao-Kun Sun

Loc X Van

Sergei A Manuilov

Chainika Jangu

Cristobal Martin Bernia

Cory M Arthur

Brett A Beiermann

Jacob S Beveridge

Ibrahim A El-Hedok

Ronald D Apple

Sheryl A Vanasse

David T Buckley

Gregory G Mehsikomer

Gregory S Mueller

Maria Del Carmen Martin Rivera

Maria Del Mar Casado Mateos

Jon T Schwartz

Bridgette R Shannon

Alireza Ghaderi

Dominic J Triana

Eli A Davis

Raghunatha K Venkatarayappa

Blake R Rustad

Abrasive articles and associated methods are shown that include abrasive particles arranged in one or more symbols on a backing substrate. Examples include shaped abrasive particles arranged into one or more symbols. Other examples include one or more wear particles with a height less than other abrasive particles, such that when exposed, the wear particles indicate a wear condition of the abrasive article.

Patterned abrasive substrate and method

The disclosure relates to, among other things, abrasive particles comprising a microparticulate layer disposed on at least a portion of the outer surface of the abrasive particles, wherein the microparticulate layer comprises microparticles dispersed in a binder and the abrasive particles are shaped abrasive particles; abrasive articles comprising such abrasive particles, including coated abrasive articles, non-woven abrasive articles, and bonded abrasive articles; and methods of making those articles.

Abrasive article with microparticle-coated abrasive grains

An abrasive article comprises abrasive particles secured to a substrate by at least one binder material. The at least one binder material comprises a cured reaction product of components comprising: a) at least one phenolic resin; and b) an aqueous dispersion of at least one polyurethane, wherein, based on the total solids weight of components a) and b), the components comprise 56 to 91 percent by weight of component a) and 44 to 9 percent by weight of component b). Methods of making and using the abrasive articles are also disclosed.

Abrasive articles and methods of making and using the same

According to one embodiment, a method can comprise: providing a tool that has a first portion that comprises a first material and a second portion that comprises a second material, wherein the second material differs from the first material and the tool is subject to a magnetic field, and wherein the first material and the second material are provided such that the magnetic field is relatively stronger at and adjacent the first portion relative to the magnetic field at and adjacent the second portion; positioning a surface adjacent to the tool so as to be subject to the magnetic field; and disposing magnetizable abrasive particles on the surface, wherein the magnetizable abrasive particles are attracted to an area on the surface adjacent the first portion where the magnetic field is relatively stronger so as to provide for at least one of a desired orientation, placement and alignment of a majority of the magnetizable abrasive particles on the surface.

Magnetically assisted disposition of magnetizable abrasive particles

Abrasive articles and associated methods are shown that include one or more camouflaging layers that can be applied to a portion of the abrasive article. The one or more camouflaging layers can be applied over the size coat layer as a discontinuous colored layer covering a portion of the size coat layer. In an example, the camouflaging layer can be applied as a repeating pattern of one or more colors on the abrasive article. In an example, the camouflaging layer can be applied randomly to the abrasive article. The discontinuous layer can have a color markedly different than a color of the size coat layer and can be used to mask or minimize an appearance of particle imperfections or voids on the abrasive article. The discontinuous layer can be applicable to coated and non-woven abrasive articles in the form of sheets, discs, belts, pads, or rolls.

Camouflage for abrasive articles

Coated abrasive articles having spacer particles are formed by providing a production tool having a dispensing surface with a plurality of cavities, guiding the production tool past an abrasive particle feeder, dispensing shaped abrasive particles onto the dispensing surface and into the plurality of cavities of the production tool, guiding a resin coated backing sheet adjacent the production tool past a spacer particle feeder, and dispensing spacer particles onto the resin coated backing sheet and/or the production tool after the abrasive particle feeder prior to a deposit point for the shaped abrasive particles. The spacer particles are selected to have a thickness that is greater than a thickness of a resin coating of the resin coating backing sheet and a thickness and density once dispensed that are sufficient to substantially prevent the production tool from contacting the resin coated backing sheet at the deposit point.

Coated abrasive article having spacer particles, making method and apparatus therefor

A repositionable abrasive disc mounting assembly comprises a backup pad and a clamp assembly. The backup pad has a rotational axis of use and a major surface with projections extending outwardly therefrom. The backup pad further comprises an inwardly facing centrally disposed first fastening member, and also an outwardly facing centrally disposed second fastening member. The clamp assembly comprises inner and outer clamp members for securing an abrasive disc. The inner clamp member comprises an inwardly facing centrally disposed third fastening member adapted to repositionably engage the second fastening member in a discrete number of rotational orientations. The inner clamp member further comprises an outwardly facing centrally disposed fourth fastening member. The outer clamp member comprises an inwardly facing centrally disposed fifth fastening member adapted to securely engage the fourth fastening member. A method of abrading a workpiece using the repositionable abrasive disc is also disclosed.

Repositionable abrasive disc mounting assembly and method of using the same

A phenolic resin composition is described comprising at least 50 wt.-% of phenolic resin; first polymerized units comprising a cationic group; and second polymerized units comprising an anionic group. The cationic groups are ionically bonded to the anionic groups. The ionic bonding of the cationic group and anionic group of the polymerized units can provide certain complex viscosity and/or tan delta properties. In some embodiments, the phenolic resin composition has a complex viscosity at 65 C of at least 50 Pascal(seconds) and/or has a tan delta at 65 C ranging from 0.5 to 2.5. Abrasive articles and methods of making an abrasive article are also described.

Phenolic resin composition comprising polymerized ionic groups, abrasive articles and methods

The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases

The present disclosure provides systems, devices, and methods for abrasive articles and manufacturing the same. A method includes receiving, at a shaped abrasive particle placement tool comprising cavities (), shaped abrasive particles (), determining whether a threshold number of cavities of the cavities () includes a shaped abrasive particle situated properly therein, in response to determining there is not a threshold number of cavities of the cavities () with a shaped abrasive particle () situated properly therein, receiving, at the shaped abrasive particle placement tool, further shaped abrasive particles, and in response to determining that at least the threshold number of cavities of the cavities () includes a shaped abrasive particle () of the shaped abrasive particles situated properly therein, releasing the shaped abrasive particles () from the shaped abrasive particle placement tool into a binding material () on a substrate () to adhere the shaped abrasive particles () to the substrate ().

Particle reception in abrasive article creation

Various embodiments of the present disclosure relate to a shaped abrasive particle transfer assembly. The shaped abrasive particle transfer assembly includes a substrate including an adhesive and a plurality of shaped abrasive particles adhered to the substrate and forming a predetermined pattern thereon.

Shaped abrasive particle transfer assembly

Apparatus includes a production tooling having a dispensing surface with a plurality of cavities and formed into an endless belt. An abrasive particle feeder dispenses shaped abrasive particles onto the dispensing surface and into the plurality of cavities. A resin coated backing receives shaped abrasive particles from the cavities of the production tooling at a deposit point. A detecting device detects a pattern transition zone as the production tooling moves in the direction of travel and provides pattern transition zone detection data to one or more controllers to control a speed of the production tooling and/or a speed of the resin coated backing as the detected pattern transition zone passes the deposit point to change a pattern density of the shaped abrasive particles in a portion of the resin coated backing corresponding to the pattern transition zone of the production tooling.

Abrasive article maker with differential tooling speed

The disclosure relates to a curable composition comprising: a polymerizable epoxy-acrylate resin composition having a complex viscosity at 25° C. and 1 Hz frequency of at least about 4500 Pa-s and a probe tack peak force of at least about 300 kPa; and abrasive particles partially or fully embedded in the polymerizable epoxy-acrylate resin composition. The disclosure also relates to cured compositions formed from such curable compositions, wherein the abrasive particles are partially or fully embedded in the cured composition. In addition, the disclosure relates to abrasive articles made from such cured compositions as well as methods for making abrasive articles.

Flexible abrasive article

A system and method for producing an abrasive article includes a production tool configured to provide shaped abrasive particles to a resin coated backing. A first end and a second end of the production tool are spliced together to form a spliced area. The production tool includes a dispensing surface that includes a plurality of cavities formed between the first end and the second end and configured to receive and hold the shaped abrasive particles. The resin coated backing is configured to receive the shaped abrasive particles from the dispensing surface of the production tool and configured to receive further shaped abrasive particles to fill gaps in the shaped abrasive particles caused by an absence of the plurality of cavities in the spliced area.

Tooling splice accommodation for abrasive article production

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

PKC-activating compounds for the treatment of neurodegenerative diseases

Growing community of inventors

Saint Paul, MN, United States of America

Thomas J Nelson