California Institute of Technology

Clinical Micro Sensors, Inc.

Northwestern University

Osmetech Technology, Inc.

Research Corporation Technologies, Inc.

Ohmx Corporation

Case Western Reserve University

Other

General Electric Company

The Johns Hopkins University

Molecular Dynamics Limited

Osmetch Technology, Inc.

Clinical Micro Systems, Inc.

Thomas J Meade

Jon Faiz Kayyem

Scott E Fraser

Stephen D O'Connor

Russell E Jacobs

Changjun Yu

Michael Gozin

Harry B Gray

Thomas W Welch

Paul A Bertin

Jost G Vielmetter

Bruce D Irvine

Robert H Terbrueggen

Gary Fife Blackburn

Michael J Ahrens

Stephen E Creager

Matthew W Rotz

James P Basilion

Dimitra Georganopoulou

Kirti Dhingra

Markus Franz Wunder

Sarah Grace Kamper

Hsiang-Hua Hung

Robert J Holbrook

Mark C Hersam

Samuel I Stupp

Martin Gilbert Pomper

Mark W Grinstaff

Ronnie Charles Mease

Vinayak P Dravid

Xing Yang

Sangeeta Ray

Annelise E Barron

Teresa K Woodruff

Ying Chen

Melvin I Simon

Dean Ho

Timothy Jay Hubin

Toshihiko Takeuchi

Allison S Harney

Steve R Bull

Amanda Eckermann

Preeti A Sukerkar

Jiyoun Lee

Ying Song

Ellen Kohlmeir

Elise A Schultz Sikma

Mohammad Aslam

Bradley D Ulrich

Lindsay K Sulzer

Renee C Strauch

Steven R Bull

Luke F Vistain

Jody L Major

Lauren M Matosziuk

Matthew J Allen

Keith W MacRenaris

Ofer Blum

Stephen J O'Connor

Lisa M Manus

Angelique Y Louie

Daniel J Mastarone

Wenhong Li

Matthew Rotz

A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.

Composition and methods for imaging cells

A method of bioactive molecule delivery includes providing a first aqueous medium comprising native graphene oxide and a second aqueous medium comprising a bioactive molecular component that includes Gd(III)-labeled molecules; mixing said first and second media to form a mixture thereof; co-incubating the mixture for a first period of time for coupling said molecular component on a surface of said native graphene oxide, to provide a co-incubation product; and contacting a cellular medium with said co-incubation product for a second period of time for cellular delivery of said bioactive molecular component.

Graphene oxide mediated cellular delivery of gadolinium-labeled molecules

Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.

Gd(III)-dithiolane gold nanoparticle conjugates

Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

Metal/radiometal-labeled PSMA inhibitors for PSMA-targeted imaging and radiotherapy

Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.

Magnetic barcode imaging

The present invention relates to MRI based imaging. In particular, the present invention provides MRI contrast agents targeted to a HaloTag protein with tunable relaxation properties thereby providing optimal relaxivity for low field strength imaging and the other optimal relaxivity for high field strength imaging. Moreover, the MRI contrast agents are used to detect gene expression (of a gene of interest) in real time in vivo, to detect changes in gene expression (of a gene of interest) over time in, for example, an individual organism, to detect gene expression changes (of a gene of interest) in response to therapeutics, in cell labeling for MR imaging, in clinical diagnostics, and in theranostics.

MRI contrast agents

The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.

Bacteria-targeted magnetic resonance contrast agents

The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.

Paramagnetic metal-nanodiamond conjugates

The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.

Chemistry used in biosensors

Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.

Magnetic resonance imaging of self-assembled biomaterial scaffolds

The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, &#x3bb;, of an electron transfer process.

Electrochemical assay for the detection of enzymes

The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.

Electronic methods for the detection of analytes

The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, &#x3bb;, of an electron transfer process.

Growing community of inventors

Wilmette, IL, United States of America

Thomas J Meade