Mimedx Group, Inc.

Shriners Hospitals for Children

University of South Florida

Shriners Hospital for Children

Shriners Hospital of Children

Mimedx, Inc.

Thomas J Koob

Mengyan Li

Daniel Hernandez

Rebeccah J C Brown

Douglas Pringle

Tian Davis

Michelle Massee

John Daniel

Randall Spencer

Young Min Ju

Francis Moussy

Kerriann Greenhalgh

Hubbard Frank Burrows, Iii

Robert Tofe

Guilhem Denoziere

Thomas Wiedrich

Rebeccah Brown

Leon Paulos

Mei Niu

W Garrett Matthews

August Heim

Elizabeth Chen

Edward Turos

Brenda S Morse

Somaly Sith

Chen-rei Wan

Rebeccah Jc Brown

Frank H Burrows, Iii

Guilhem Denozière

Kirk Joseph Naizer

Frank Burrows

Rebeccah JC Brown

H Frank Burrows

Adam McQueen

This invention is directed to a multi-layered tissue graft comprising a collagen layer and at least one separated and washed placental tissue component and/or umbilical cord component, wherein the collagen is human collagen substantially free of non-human antigens.

Collagen reinforced tissue grafts

Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.

Reinforced placental tissue grafts and methods of making and using the same

Provided herein are micronized placental compositions composed of micronized placental tissue component, such as amnion or chorion and/or filler bound to one or more chelating agents, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. Further provided are methods of making and using the placental compositions. The compositions have numerous therapeutic applications.

Micronized placental compositions comprising a chelator

Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.

Collagen and micronized placental tissue compositions and methods of making and using the same

The present disclosure provides compositions composed of amniotic fluid and/or modified amniotic fluid, a pharmaceutically acceptable carrier, and optionally a placental tissue graft, micronized placental tissue components, or extracts derived therefrom. Also described are systems and apparatuses for administering or storing said compositions, as well as methods of treatment using said compositions.

Compositions and methods of treatment with amniotic fluid

Described herewith are compositions comprising placental growth factors and methods for non-surgical, localized delivery thereof. The composition is delivered to a diseased or injured organ and/or body part and is formulated in a manner which allows for localized retention of the composition at the site of delivery.

Non-surgical, localized delivery of compositions for placental growth factors

Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.

Methods for treating cardiac conditions

Described herein are dehydrated, laminated tissue grafts composed of two or more membrane layers of an amnion membrane, a chorion membrane, a Wharton's jelly, or an intermediate tissue layer, where a layer of micronized placental tissue is interposed between two of the layers. Also described herein are methods for making and using the laminated tissue grafts.

Tissue grafts composed of micronized placental tissue and methods of making and using the same

Implantable medical constructs formed by winding using winding support structures that can be flexible and can be integrated into the medical construct with biocompatible fiber(s) and/or yarn(s) and at least one continuous length collagen fiber. The implantable medical construct can include open suture anchor apertures formed using posts during a winding sequence.

Methods of making collagen fiber medical constructs and related medical constructs, including patches

The present disclosure describes a medical construct. The medical construct includes a first layer comprising an array of collagen fibers, the first layer forming a core of the medical construct, and a second layer comprising a plurality of braided collagen fibers, wherein the second layer surrounds the core of the medical construct. In some embodiments, the medical construct may further include a third layer comprising a plurality of braided collagen fibers, wherein the third layer surrounds the second layer. Methods of manufacturing a medical construct also provided.

Collagen constructs and methods of making the same

Described herein are compositions and methods of using placental stem cell recruiting factors, more specifically, isolated placental stem cell recruiting factors. In one embodiment, isolated placental stem cell recruiting factors are delivered to a site such as a diseased or injured organ and/or body part in an amount sufficient to recruit stem cells to the site.

Isolated placental stem cell recruiting factors

Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.

Molded placental tissue compositions and methods of making and using the same

Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in wound healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of chorion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.

Placental tissue grafts modified with a cross-linking agent and methods of making and using the same

Placental tissue composition for for treating cardiac tissue damage

Growing community of inventors

Kennesaw, GA, United States of America

Thomas J Koob