Air Products and Chemicals, Inc.

Illumina Corporation

Other

Kontes Glass Corp.

Thomas J Joseph

Helmy A Eltoukhy

Xiaohai Liu

Jonathan Mark Boutell

Robert C Kain

Geoffrey Paul Smith

Wenyi Feng

Xiaolin Wu

Min-Jui Richard Shen

Bernard Hirschbein

Randall Smith

Kay Klausing

Carolyn Tregidgo

Vladimir Yliy Gershtein

Paul Anthony Mattiola

Derek Miller

Karen Marie Campbell

Paul A Mattiola

Phillip William Eckels

David Jonathan Chalk

Alexander P Varghese

Joseph Anthony Schillinger

Omar A Swift

Robert C Adams

Alfred J Pearson

David D Nguyen

Kwang-Fu P Hwang

The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Methods and compositions for nucleic acid sequencing

Systems and methods are provided for distributing a product, like hydrogen, contained in a carrier to a user, and for recovering the spent from the user. In one embodiment, the invention is a system for distributing a product releasably incorporated within a carrier, recovering spent, and conveying spent to a rehabilitation facility. In this embodiment, the system comprises a mobile delivery vehicle, the vehicle comprising a first storage vessel for storing fresh and for dispensing fresh using a connected fresh dispensing apparatus and for receiving and storing spent from a spent dispensing apparatus, the storage vessel further including means for separating fresh from spent. The system further includes fresh, spent, and a first user. The first user comprises a fresh storage vessel for receiving, storing, and dispensing fresh, and further comprises a first spent storage vessel for receiving, storing, and dispensing spent. The system further includes a fresh dispensing apparatus for linking the first storage vessel and the fresh storage vessel of the first user for dispensing of fresh to the first user, and a spent removal apparatus for linking the first storage vessel and the spent storage vessel of the first user for removal of fresh from the first user for storage in the first storage vessel. Use of a mobile delivery vehicle to deliver fresh and recover spent for rehabilitation from a plurality of users avoids logistic inefficiencies, and reduces potential for contamination and/or loss of product, carrier, fresh, and spent.

Efficient system and method for delivery of product and return of carrier

Systems and methods for supply and delivery of a product incorporated into a carrier are provided. In one embodiment, the invention comprises a system that comprises a fresh storage vessel for receiving and storing fresh. The system further includes a fresh transferring apparatus communicably linked to the fresh storage vessel for transferring of fresh to a user when the user is connected to the transferring apparatus. The system further includes a spent storage vessel for receiving and storing spent (spent being defined as fresh with at least some product and/or product element removed therefrom), and a spent transferring apparatus communicably linked to the spent storage vessel for transferring spent from a user when the user is connected to the transferring apparatus. Optionally, the system further includes of an intermediate spent storage vessel disposed in the communicable connection between the spent transferring apparatus and the spent storage vessel. The intermediate spent storage vessel optionally includes a controllable communicable connection for selective transfer of spent from the intermediate storage vessel to a contamination storage vessel or the spent storage vessel. The carrier may be in any physical state or any combination thereof. In addition, the carrier may involve any known mechanism to capture, retain, or release product, for example, chemical reaction, adsorption, dilution, among others.

Method and system of supply and delivery of product contained in a carrier

Systems and methods for distributing a product releasably incorporated within a carrier, and for removing the product and returning the carrier for rehabilitation. In one embodiment, the system includes a first supply loop comprising a manufacturing facility for releasably incorporating a product into a first carrier to form fresh. The first loop further includes transportation means for conveying fresh to a first user, the first user including a fresh storage vessel for receiving and storage of fresh. The first user further comprises means for removing product from the carrier to form spent, and a spent storage vessel for receiving, storing, and dispensing of spent. The loop further includes means for returning the spent to a rehabilitation facility of the spent to form fresh wherein a product is contained in a carrier. The carrier may be in any physical state such as for example, solid, liquid, vapor, plasma, or any combination thereof. In addition, the carrier may involve any known mechanism to capture, retain, or release product, for example, chemical reaction, adsorption, dilution, among others. Optionally, the invention comprises a second supply loop that received product liberated from the first supply loop, without exchanging carrier, fresh, or spent with the first supply loop. The invention thus provides for product transfer efficiently and economically with minimal possible losses of the carrier quantity and quality. Contamination of a carrier and/or unintended mixing of different carriers is avoided, or at least localized to limited quantities.

Secure loop system and method for supply and delivery of product contained in a carrier

An open architecture recondensing superconducting magnet utilizing an upper and lower cryogen vessel connected by a passageway which extends above the bottom of upper cryogen vessel to discontinue the flow of liquid cryogen through the passageway to reserve liquid cryogen in the upper cryogen vessel when the cryogen level falls to provide an increased ride-through period in the event of a depleting liquid cryogen supply due to failure of the cryogen gas recondenser. A signal is provided to indicate the need to correct the failure.

Superconducting magnet split cryostat cryogen ride-through reserve

An assembly and method for supporting a plurality of individually insulated pipes or conduits inside a vacuum jacket where the insulated pipes are positioned or fixed relative to one another and the inside surface of the vacuum jacket.

Support system and method for jacketed multiple cryogenic pipes for

Apparatus is disclosed that removably attaches to the top platform of a stepladder, the apparatus includes a plate mounted to the stepladder, a bucket receptacle disposed on top of the plate, the bucket receptacle being used to hold items such as paint cans, nails or cleaning implements therein. The bucket receptacle is provided with tapered sides and a gasket to securely hold a paint can therewithin. The apparatus also includes one or more side attachments disposed on top of the plate integrally connected with the bucket receptacle. The side attachments are formed with various recesses or tool support shelves for securely holding various implements such as power tools, hand tools, paintbrushes or cleaning implements.

Detachable device-holding apparatus for a stepladder

In a chromatography column one or more of the end plates defining the column are provided with specially designed lands and grooves to more effectively uniformly distribute the input liquid over the column cross-sectional area and thus improve the separation of sample components, the upper end wall of the column being adjustably positionable to vary the axial length of the column by means of novel structure including readily releasable speed nuts engageable with externally threaded rods, the seal between the movable upper plate and the column wall being so designed as to minimize dead space and thus further increase separating power, and the structure for adjustably positioning said top wall includes elements enabling that structure and the top wall connected thereto to be conveniently supported in inverted condition when separated from the remainder of the column structure.

Chromatography column

Growing community of inventors

Hampden, MA, United States of America

Thomas J Joseph