Merck Patent Gmbh

Henkel Ag & Company, Kgaa

Merck Patent Gesellschaft MIT Beschrankter Haftung

Thomas J J Mueller

Dieter Dorsch

Eugen Merkul

Christian Sirrenberg

Margarita Wucherer-Plietker

Christian Kropf

Gnuni Karapetyan

Thomas Gerke

Ursula Huchel

Lars Thore Burgdorf

Christina Esdar

Alexander Schulz

Sascha Schaefer

Christian Umbreit

Michael Strotz

Christian Sirenberg

Bernhard Mayer

Melanie Denissen

Julian Papadopoulos

Jan Nordmann

Margarita Wucherer-plietker

Margarita Wuchrer

The present invention relates to the use of substituted bis-4H-pyranonyl compounds in which the 4H-pyranonyl units are combined with heteroalkyl groups, in detergents and cleaning agents, for improving detergent or cleaning performance with respect to bleachable stains.

Detergents and cleaning agents having improved performance

The disclosure relates to special orthoformic acid esters of formula (I), as defined herein, which can be used as thermally labile and acid-labile fragrance storage substances. The disclosure further relates to detergents and cleaning agents, cosmetic agents and air freshening products containing such orthoformic acid esters, as well as to a method for lastingly fragrancing surfaces.

Orthoformic acid esters as pro-fragrances

Compounds of the formula (I) in which R, R, Rand Rhave the meanings indicated in Claim, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

7-azaindole derivatives

Compounds of the formula (I), in which R, R, Rand Rhave the meanings indicated in Claim, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives

The deliberate release of odorants or aroma substances is desirable in many fields of application, and in particular in the field of washing and cleaning agents. Said deliberate release is achieved by using an odorant composition that comprises an odorant precursor, which is an allyl ether of the formula (I), RRC&#x2550;CR&#x2014;CRR&#x2014;O&#x2014;CHRR, in which the residues R, R, R, R, R, Rand Rmutually independently denote H or a hydrocarbon residue that can be acyclic or cyclic, substituted or unsubstituted, branched or unbranched, as well as saturated or unsaturated. Thus, in particular odorants in the form of an alkene having an allylic hydrogen atom, such as &#x3b1;-pinene, can be released in a deliberate manner.

Odorant composition containing allyl ethers as odorant precursors

Compounds of the formula (I) in which R, R, Rand Rhave the meanings indicated in claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

The invention relates to compounds the formula (I): and pharmaceutically usable salts, tautomers and stereoisomers thereof, wherein R, Rand Rare defined herein. The compounds of formula (I) and their pharmaceutically usable salts, tautomers and stereoisomers are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

Substituted 7-(1,2,3-Triazol-4-yl)-pyrrolo[2,3-b]pyrazines

Compounds of the formula (I), in which R, R, R, Rand Rhave the meanings indicated in Claim, are inhibitors of cell proliferation\cell vitality and can be employed for the treatment of tumors.

4 (pyrrolopyridinyl)pyrimidin-2-ylamine derivatives

Compounds of the formula (I), in which R, R, Rand Rhave the meanings indicated in claim (), are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumors. 

6-(pyrrolopyridinyl) pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and AIDS

Compounds of the formula (I), in which R, Rand Rhave the meanings indicated in claim (), are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumors.

3-(1,2,3-triazol-4-yl) pyrrolo [2,3-b] pyridine derivatives

Compounds of the formula (I), in which R, R, R, Rand Rhave the meanings indicated in claimare inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumors.

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Duesseldorf, Germany

Thomas J J Mueller