The General Hospital Corporation

Other

Thomas J Brady

Alexei A Bogdanov

Ralph Weissleder

Homer Pien

William C Karl

Zhuangli Liang

Mikhail I Papisov

Rajiv Gupta

Synho Do

Randall B Lauffer

Ronald Callahan

A system and method for producing an image of a subject with a tomographic imaging system are provided. A tomographic imaging system is operated to rotate a radiation detector, radiation source, or both through a plurality of angular positions around a subject while acquiring data. As the radiation detector or source is rotated, the radiation detector or source is shifted at each angular position by a different shift value. An image of the subject is reconstructed from the acquired data using a reconstruction technique that incorporates the shifts applied to the detector, source, or both into a system matrix.

System and method for ultra-high resolution tomographic imaging

In one aspect, the invention is a method of medical image processing. The method includes receiving data representing a medical image. The method also includes generating the medical image based on a model. The model characterizes the medical image as a composition of at least two components having processing constraints.

Medical image processing

In one aspect, the invention is a method to reduce a blooming effect of a bright object in a medical image generated from a low-dose imaging system. The method includes characterizing an ideal image as a composition of a first component and a second component. The first component is characterized by a first function and the second component is characterized by a second function. The method also includes minimizing the first function and the second function using a smoothing process and generating the medical image based on the minimizing.

A biocompatible graft co-polymer adduct including a polymeric carrier, a protective chain linked to the polymeric carrier, a reporter group linked to the carrier or to the carrier and the protective chain, and a reversibly linked Pt(II) compound. The invention also relates to a method of treating a disease in a patient, particularly cancer, by administering to the patient a therapeutically effective amount of the adduct, and may include scanning the patient using an imaging technique which can provide a visible image of the distribution of the adduct.

Graft co-polymer adducts of platinum (II) compounds

The invention features a method of blood pool imaging which utilizes an imaging agent which can be easily labelled with a radioactive isotope and injected into a patient. The imaging agent is a covalent conjugate of a polymeric carrier, protective groups, and chelating groups. The imaging agent is preferably provided in the form of a blood pool imaging composition, which includes an imaging agent of the invention, a buffer and a reducing compound. A radioactive isotope is added to the blood pool imaging composition to label the imaging agent, and the composition containing the labelled imaging agent is injected intravenously into a patient.

Blood pool imaging composition and method of its use

A biocompatible medical composition including a polymeric carrier, a protective chain linked to the polymeric carrier, and a reporter group linked to the carrier or to the carrier and the protective chain. The invention also relates to a method of treating a disease in a patient by administering to the patient a therapeutically effective amount of the composition, and may include scanning the patient using an imaging technique which can detect the reporter group to obtain a visible image of the distribution of the composition.

Medical compositions

A substance for diagnosis or therapy of an animal. The substance includes an agent which is detectable or therapeutically active, the agent being linked to a carrier which is linked to a targeting site, whereby the agent accumulates in the lymphatic system of the animal to a greater degree than if the targeting site were absent.

System of drug delivery to the lymphatic tissues

A waterproof pouch includes a readily openable and recloseable waterproof seal protected by a closure flap having readily openable and recloseable fastening means. The pouch also includes a readily openable and closeable clamp for clamping the pouch to wearing apparel.

Waterproof pouch releasably clampable to wearing apparel

A method of altering proton NMR relaxation times in the liver or bile duct of a human patient involving administering to the patient an agent characterized in that it is taken up preferentially by human hepatocytes, compared to human reticuloendothelial cells, and it contains a paramagnetic substance capable of altering the proton NMR relaxation times in the hepatocytes.

Growing community of inventors

Winchester, MA, United States of America

Thomas J Brady