Aprecia Pharmaceuticals LLC

Aprecia Pharmaceuticals Company

Therics, Inc.

Thomas J Bradbury

Thomas George West

Jaedeok Yoo

Henry Leon Surprenant

James Iskra

Thomas J Bebb

Mahendra R Patel

Aleece M Phillips

Peter A Materna

Christopher M Gaylo

Amit S Patel

Kathleen D Chesmel

Henry L Surprenant

Thomas G West

Qing Wen Liu

James A Fairweather

Donald C Monkhouse

Chen-Chao Wang

Timothy J Pryor

Kelly E Caputo

Alfred Anthony Litwak

Sunil Saini

Matthew F Boldt

Munhee Lee

Timothy S Tracy

Henry Cabral

Heather Ann Beam

Jennifer Patterson

Adolphe Youssef

Lauren E Beach-Herrera

William R Gross

A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside.

Rapidly-orodispersible tablets having an interior cavity

A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.

Three-dimensional printing system and equipment assembly

Rapidly-orodispersible tablets having an in interior cavity

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.

Method and system for forming a dosage form within a packaging

An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.

Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications

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Yardley, PA, United States of America

Thomas J Bradbury