Pall Corporation

Merck + Co., Inc.

Thomas J Bormann

Vlado I Matkovich

Thomas C Gsell

Frank R Pascale

Gerard R DelGiacco

Mladen Franovic

David B Pall

Eric J Krasnoff

Samuel T Wortham

Keith S Morris

Byron Selman

Duane Piechocki

Peter J Degen

Benjamin Janes Beck

Isaac Rothman

YoungMihn Kim

Thomas Burchard

Stephen Guerrera

Thomas E Schlaudecker

Galina Fomovska

Martin W Henley

Gerard R Del Giacco

Gerard Delgiacco

Mikhail Fomovsky

Gerald R Delgiacco

A method of making a sterile connection comprises mating a first fitting having an aperture and a second fitting having an aperture, removing first and second strip out layers from between the end surfaces of sealed first and second resilient sealing members, and contacting the end surfaces of the resilient sealing members to provide fluid communication between the aperture of the first fitting and the aperture of the second fitting. A connector assembly comprises first and second fittings, a stem mounted for axial movement through the first fitting into the second fitting, and a deformable locking device which selectively prevents axial movement of the stem in the first fitting.

Methods for making a connection

Devices and methods for separating plasma from biological fluids such as blood and blood products are disclosed.

Plasma separation

A connector assembly and a fluid system or device comprises a connector assembly which includes first and second fittings, each fitting having an aperture, a first cap, and a stem disposed in the aperture of the first fitting. In various embodiments of the invention, the connector assembly further comprises a socket cooperatively arranged with one of the first and second fittings and at least one resilient sealing member. A method for making a connection includes removing a cap, mating first and second fittings, removing a stripout layer, and establishing a fluid flowpath through the first and second fittings.

Connector assemblies and methods for making a connection

A filter device () comprising a filter () for producing a leukocyte-depleted plasma-rich fluid is disclosed.

Biological fluid filter and system

A connector or a connector assembly comprises a fitting, a resilient sealing member, a plurality of protrusions, and a removable stripout layer. The fitting includes a socket. The protrusions extend from the fitting and are connectable to a mating connector. The resilient sealing layer, which is disposed in the socket of the fitting, includes a hollow body having opposite open ends and an internal passage extending between the open ends. The removable stripout layer is movable between a first position in which the stripout layer overlies an end of the resilient sealing member and a second position in which the stripout layer is removed from the end of the resilient sealing member.

Connector assembly

A filter for processing a biological fluid is disclosed comprising at least two filter elements wherein the surface of one filter element is substantially non-hydroxylated and has a nitrogen-to-oxygen ratio in the range of from at least 0.01 to less than about 1.00, and the surface of the other filter element is hydroxylated relative to the bulk of the element.

Connectors, connector assemblies, fluid systems, and method for making a connection

A connector assembly and a fluid system or device comprise a connector assembly which includes first and second fittings, each fitting having an aperture, and a stem disposed in the aperture of the first fitting. In various embodiments of the invention, the connector assembly may further comprise a socket cooperatively arranged with one of the first and second fittings, at least one resilient sealing member, a sealing layer joined to the socket or covering the resilient sealing member, and/or a deformable locking device. A method for making a connection includes mating a first fitting having an aperture and a second fitting having an aperture without fluid within the first and second fittings, establishing a fluid flowpath through the first and second fittings by advancing a stem having a head through the aperture of the first fitting into the aperture of the second fitting, and establishing fluid flow through the first and second fittings by opening a fluid blocking mechanism.

Connector assemblies, fluid systems, and methods for making a connection

A device ( ) such as a drip chamber that can be filled to a predetermined level is disclosed. The device comprises a housing ( ) and a porous medium ( ), wherein the porous medium allows gas to pass therethrough.

Priming system

A method for automatically processing a biological fluid is disclosed. The method includes the steps of obtaining a container having a biological fluid therein, providing a first signal and communicating with an automated control arrangement to establish flow of at least a portion of the biological fluid along a fluid flow path through a leukocyte depletion medium, providing a second signal and communicating with the automatic control arrangement to terminate flow along the fluid flow path wherein providing the second signal includes sensing the back pressure in the fluid flow path or the flow rate through the leukocyte depletion medium.

Automated method for processing biological fluid

A biological fluid filter assembly (,) including a plurality of porous media (,) and essentially lacking a solid partition between the media is disclosed. Preferably, the assembly has a space (,) between the media (,). The filter assembly is especially suitable for depicting leukocytes from a biological fluid such as packed red cells, and can be used to deplete leukocyts from two or more units of biological fluid. A method of using the filter assembly is also provided.

Multiple element filter and method of using therefor

An automated system for processing biological fluid includes a pressure differential generator, a biological fluid processing assembly, and an automated control arrangement coupled to at least one of the pressure differential generator and the biological fluid processing assembly. The automated system may include a porous medium, such as a red cell barrier medium, a leukocyte depletion medium, or a combination red cell barrier/leukocyte depletion medium. The automated system may also include a sensor producing a signal reflecting a parameter of fluid flow.

Automated system and method for processing biological fluid

Leucocyte depletion filter assemblies decrease the leucocyte content of a leucocyte-containing liquid at a flow rate of greater than about 25 milliliters per minute. These filter assemblies are suitable for use in an extracorporeal circuit. Methods for removing leucocytes and other deleterious matter are also disclosed.

Leucocyte depleting filter device and method of use

The present invention provides for processing a biological fluid such as blood, to separate at least one component from the biological fluid, and to remove leukocytes from the separated component while returning the component depleted biological fluid to the source of the fluid. Illustratively, blood is obtained from a source such as a donor, and platelets are separated from the bold. Gas is separated from the flow path of the separated platelets, which are depleted of leukocytes, while platelet depleted blood is returned to the donor.

Method for separating components from a biological fluid

A system for processing a biological fluid by spirally passing the biological fluid along at least one first flow path along the first surface of a separation medium in a separation device is disclosed. Also disclosed is a system for processing a biological fluid utilizing a plurality of pressure differential generators including enclosed chambers.

Growing community of inventors

Melville, NY, United States of America

Thomas J Bormann