Evonik Degussa Gmbh

Evonik Operations Gmbh

Evonik Industries Ag

Thomas Hueller

Oliver Thum

Thomas Haas

Steffen Schaffer

Marco Alexander Van Den Berg

Jan Christoph Pfeffer

Frank Erhardt

Eva Maria Wittmann

Christian Gehring

Frank Hellmers

Thomas Dassinger

Sabine Hafkemeyer

Daniel Boergel

The invention provides granules comprising

Granules comprising isomaltulose synthase

The invention relates to a method for oxidizing an alkane, comprising contacting the alkane with a type alkB oxidoreductase and using a type alkB oxidoreductase to prepare a mixture of oxidation products of an alkane, wherein the ratio of carboxylic acid to alcohol in the oxidation products is preferably greater than 1:1.

Biological alkane oxidation

The present invention provides genetically engineered microbial strains, in particular genetically engineered yeast strains, that produce at least 0.5 mg per g CDW of a sphingoid base according to Formula I or a salt or ester thereof. The present invention provides a method to obtain genetically engineered microbial strains producing at least 0.5 mg per g CDW of a sphingoid base according to Formula I or a salt or ester thereof. The method comprises the steps of: a) increasing the expression of a polynucleotide encoding an enzyme having ceramide synthase activity and/or an enzyme having ceramidase activity, the latter being capable of preferentially, or even specifically, hydrolyzing ceramides containing a sphingoid base according to Formula I, and/or b) decreasing the expression of a polynucleotide encoding an enzyme having sphingolipid &#x394;8-desaturase activity and/or an enzyme having ceramidase activity, the latter being capable of preferentially, or even specifically, hydrolyzing ceramides containing phytosphingosine or dihydrosphingosine as sphingoid base, and isolating strains with the required productivity.

Method for obtaining a microbial strain for production of sphingoid bases

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Marl, Germany

Thomas Hueller